Evidence map›Paper›PMID 37047686›Full record

ArticleInternational journal of molecular sciences2023

Co-Culture of Mesenchymal Stem Cells and Ligamentocytes on Triphasic Embroidered Poly(L-lactide-co-ε-caprolactone) and Polylactic Acid Scaffolds for Anterior Cruciate Ligament Enthesis Tissue Engineering.

Clemens Gögele, Julia Vogt, Judith Hahn, Annette Breier, Ricardo Bernhardt, Michael Meyer, Michaela Schröpfer, Kerstin Schäfer-Eckart, Gundula Schulze-Tanzil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Clemens GögeleInstitute of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg and Salzburg, Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany.ORCID 0000-0002-7086-9743
Julia VogtInstitute of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg and Salzburg, Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany.
Judith HahnDepartment Materials Engineering, Institute of Polymers Materials, Leibniz-Institut für Polymerforschung Dresden e.V. (IPF), Hohe Straße 6, 01069 Dresden, Germany.ORCID 0000-0003-0362-9018
Annette BreierDepartment Materials Engineering, Institute of Polymers Materials, Leibniz-Institut für Polymerforschung Dresden e.V. (IPF), Hohe Straße 6, 01069 Dresden, Germany.
Ricardo BernhardtDepartment Materials Engineering, Institute of Polymers Materials, Leibniz-Institut für Polymerforschung Dresden e.V. (IPF), Hohe Straße 6, 01069 Dresden, Germany.ORCID 0000-0001-8471-9693
Michael MeyerFILK Freiberg Institute gGmbH (FILK), Meißner Ring 1-5, 09599 Freiberg, Germany.ORCID 0000-0003-2934-9962
Michaela SchröpferFILK Freiberg Institute gGmbH (FILK), Meißner Ring 1-5, 09599 Freiberg, Germany.ORCID 0000-0002-1441-6336
Kerstin Schäfer-EckartBone Marrow Transplantation Unit, Medizinische Klinik 5, Klinikum Nürnberg, 90419 Nuremberg, Germany.
Gundula Schulze-TanzilInstitute of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg and Salzburg, Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany.ORCID 0000-0002-9807-9532
Leibniz Institute of Polymer Research · DEParacelsus Medizinische Privatuniversität · DEForschungsinstitut für Leder und Kunststoffbahnen · DENuremberg Hospital · DE

Funding

Deutsche Forschungsgemeinschaft SCHU1979/14-1
6 · The paper itself

Abstract

Successful anterior cruciate ligament (ACL) reconstructions strive for a firm bone-ligament integration. With the aim to establish an enthesis-like construct, embroidered functionalized scaffolds were colonized with spheroids of osteogenically differentiated human mesenchymal stem cells (hMSCs) and lapine (l) ACL fibroblasts in this study. These triphasic poly(L-lactide-co-ε-caprolactone) and polylactic acid (P(LA-CL)/PLA) scaffolds with a bone-, a fibrocartilage transition- and a ligament zone were colonized with spheroids directly after assembly (DC) or with 14-day pre-cultured lACL fibroblast and 14-day osteogenically differentiated hMSCs spheroids (=longer pre-cultivation, LC). The scaffolds with co-cultures were cultured for 14 days. Cell vitality, DNA and sulfated glycosaminoglycan (sGAG) contents were determined. The relative gene expressions of

Indexed as

Mesenchymal Stem CellsTissue EngineeringAnterior Cruciate LigamentCaproatesCells, CulturedCoculture TechniquesCollagen Type IDioxanesHumansLactonesPolyestersTissue ScaffoldsCaproatescaprolactoneCollagen Type IdilactideDioxanesLactonesPolyesterspoly(lactide)anterior cruciate ligamentco-cultureenthesismedical lace embroiderypoly(L-lactide-co-ε-caprolactone) (P(LA-CL))/polylactic acid (PLA)tissue engineeringtriphasic scaffold

Identifiers

PMID37047686
PMCPMC10095212
OpenAlexW4362559361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.