Evidence map›Paper›PMID 37047666›Full record

ArticleInternational journal of molecular sciences2023

TLR9 Signaling Is Required for the

Ali Alaqla, Yang Hu, Shengyuan Huang, Sunniva Ruiz, Toshihisa Kawai, Xiaozhe Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Regulatory B Cells in Tumor Microenvironment.Current issues in molecular biology · 2026
    Review
  2. Expansion of B10 cellsInternational journal of molecular medicine · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ali AlaqlaDepartment of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
Yang HuDepartment of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
Shengyuan HuangDepartment of Oral Science and Translation Research, College of Dental Medicine, Nova Southeastern University, 3301 College Ave., Fort Lauderdale, FL 33314, USA.
Sunniva RuizDepartment of Oral Science and Translation Research, College of Dental Medicine, Nova Southeastern University, 3301 College Ave., Fort Lauderdale, FL 33314, USA.
Toshihisa KawaiDepartment of Oral Science and Translation Research, College of Dental Medicine, Nova Southeastern University, 3301 College Ave., Fort Lauderdale, FL 33314, USA.
Xiaozhe HanDepartment of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.ORCID 0000-0001-8357-1471
Harvard University · USNova Southeastern University · US

Funding

Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal DiseaseR01DE025255 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2015 to 2025
$5.8M
Role of OC-STAMP expressed on human osteoclasts in periodontitisR01DE029709 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI KAWAI, TOSHIHISA · 2020 to 2025
$2.8M
Role of platelets in periodontal bone remodeling.R15DE027851 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI KAWAI, TOSHIHISA · 2019 to 2020
$596k
POC Biosensor for PeriodontitisR21DE028715 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI KAWAI, TOSHIHISA · 2020 to 2021
$454k
NIDCR NIH HHS R01 DE025255NIDCR NIH HHS R01 DE029709NIDCR NIH HHS R15 DE027851NIDCR NIH HHS R21 DE028715NIH HHS R01DE025255
6 · The paper itself

Abstract

Immune cell pattern-recognition receptors such as Toll-like receptors (TLRs) play important roles in the regulation of host responses to periodontal pathogens. Our previous studies have demonstrated that immune regulatory B cells were activated by TLRs and alleviated periodontitis inflammation and bone loss. The purpose of this study is to determine the role of TLR9 signaling in the activation and IL-10 production of the primed-immune B cells in vitro. Wild-type (WT) and TLR9 knockout (TLR9KO) mice (C57BL/6 background,

Indexed as

Interleukin-10Toll-Like Receptor 9AnimalsB-LymphocytesCells, CulturedMiceMice, Inbred C57BLMice, KnockoutPorphyromonas gingivalisRNA, MessengerToll-Like ReceptorsInterleukin-10RNA, MessengerTlr9 protein, mouseToll-Like Receptor 9Toll-Like Receptorsadaptive immune responseB10 cellsperiodontal diseaseP. gingivalisTLR-9

Identifiers

PMID37047666
PMCPMC10094902
OpenAlexW4362559696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.