Evidence map›Paper›PMID 37047663›Full record

ArticleInternational journal of molecular sciences2023

Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance.

Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarrone

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Chronic palmitoylethanolamide administrationFrontiers in cellular neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lucia ScipioniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio Snc, 67100 L'Aquila, Italy.
Daniel TortolaniEuropean Center for Brain Research-IRCCS Santa Lucia Foundation (FSL), Via del Fosso di Fiorano 64, 00143 Rome, Italy.ORCID 0000-0002-6704-9023
Francesca CiaramellanoEuropean Center for Brain Research-IRCCS Santa Lucia Foundation (FSL), Via del Fosso di Fiorano 64, 00143 Rome, Italy.ORCID 0000-0002-1899-8628
Federico FantiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0002-9235-5874
Thais GazziLeibniz Research Institute for Molecular Pharmacology (FMP), Campus Berlin-Buch, 13125 Berlin, Germany.
Manuel SergiDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, Italy.
Marc NazaréLeibniz Research Institute for Molecular Pharmacology (FMP), Campus Berlin-Buch, 13125 Berlin, Germany.
Sergio OddiEuropean Center for Brain Research-IRCCS Santa Lucia Foundation (FSL), Via del Fosso di Fiorano 64, 00143 Rome, Italy.ORCID 0000-0002-6217-698X
Mauro MaccarroneDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio Snc, 67100 L'Aquila, Italy.ORCID 0000-0002-3990-2963
University of Teramo · ITLeibniz Association · DEUniversity of L'Aquila · ITSapienza University of Rome · IT

Funding

Italian Ministry of University and Research 2017BTHJ4R_001Italian Ministry of University and Research 2017BTHJ4R_005
6 · The paper itself

Abstract

Dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate Alzheimer's disease (AD) pathogenesis by releasing proinflammatory factors, such as nitric oxide (NO). The endocannabinoids

Indexed as

Alzheimer DiseaseMicrogliaAmyloid beta-PeptidesAnimalsEndocannabinoidsMiceMice, TransgenicReceptors, CannabinoidSignal TransductionAmyloid beta-PeptidesEndocannabinoidsReceptors, CannabinoidAlzheimer’s diseaseendocannabinoid systemmicrogliaβ-amyloid peptides

Identifiers

PMID37047663
PMCPMC10095368
OpenAlexW4362559736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.