Evidence map›Paper›PMID 37047606›Full record

ArticleInternational journal of molecular sciences2023

Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction.

Hikari Amemiya, Masahito Yamamoto, Kazunari Higa, Genji Watanabe, Shuichiro Taniguchi, Kei Kitamura, Juhee Jeong, Nobuaki Yanagisawa, Ken-Ichi Fukuda, Shinichi Abe

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Hikari AmemiyaDivision of Special Needs Dentistry and Orofacial Pain, Department of Oral Health and Clinical Science, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Masahito YamamotoDepartment of Anatomy, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.ORCID 0000-0001-9683-6678
Kazunari HigaOphthalmology/Cornea Center, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba 272-8513, Japan.
Genji WatanabeDepartment of Anatomy, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Shuichiro TaniguchiDepartment of Anatomy, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Kei KitamuraDepartment of Histology and Developmental Biology, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Juhee JeongDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 E. 24th Street, New York, NY 10010, USA.
Nobuaki YanagisawaDivision of Oral Health Sciences, Department of Health Sciences, School of Health and Social Services, Saitama Prefectural University, 820 Sannomia, Koshigaya-shi, Saitama 343-0036, Japan.
Ken-Ichi FukudaDivision of Special Needs Dentistry and Orofacial Pain, Department of Oral Health and Clinical Science, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Shinichi AbeDepartment of Anatomy, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.ORCID 0000-0003-4632-9736
Tokyo Dental College · JPNew York University · USSaitama Prefectural University · JPTokyo Dental College Ichikawa General Hospital · JP

Funding

Genetic regulation of embryonic head mesenchyme patterningR01DE026798 · NIDCR · NEW YORK UNIVERSITY · PI JEONG, JUHEE · 2017 to 2021
$2.1M
NIDCR NIH HHS R01 DE026798
6 · The paper itself

Abstract

Myostatin (Myo) is known to suppress skeletal muscle growth, and was recently reported to control tendon homeostasis. The purpose of the present study was to investigate the regulatory involvement of Myo in the myotendinous junction (MTJ) in vivo and in vitro. After Achilles tendon injury in mice, we identified unexpected cell accumulation on the tendon side of the MTJ. At postoperative day 7 (POD7), the nuclei had an egg-like profile, whereas at POD28 they were spindle-shaped. The aspect ratio of nuclei on the tendon side of the MTJ differed significantly between POD7 and POD28 (

Indexed as

Achilles TendonMyotendinous JunctionAnimalsMiceMusclesMuscle, SkeletalMyostatinNIH 3T3 CellsMyostatinAchilles tendon injuryC2C12myostatinmyotendinous junctionNIH3T3

Identifiers

PMID37047606
PMCPMC10094852
OpenAlexW4362583572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.