Evidence map›Paper›PMID 37047600›Full record

ReviewInternational journal of molecular sciences2023

Towards a More Realistic In Vitro Meat: The Cross Talk between Adipose and Muscle Cells.

Margherita Pallaoro, Silvia Clotilde Modina, Andrea Fiorati, Lina Altomare, Giorgio Mirra, Paola Scocco, Alessia Di Giancamillo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Birth Season and Breed Effects on NewbornAnimals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Preparation of COACS biomaterials science & engineering · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Margherita PallaoroDepartment of Veterinary Medicine and Animal Sciences (DIVAS), University of Milan, Via dell'Università 6, 26900 Lodi, Italy.ORCID 0000-0002-8292-4543
Silvia Clotilde ModinaDepartment of Veterinary Medicine and Animal Sciences (DIVAS), University of Milan, Via dell'Università 6, 26900 Lodi, Italy.ORCID 0000-0002-2780-5971
Andrea FioratiDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Polytechnic University of Milan, Via Luigi Mancinelli, 7, 20131 Milan, Italy.ORCID 0000-0002-2260-0563
Lina AltomareDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Polytechnic University of Milan, Via Luigi Mancinelli, 7, 20131 Milan, Italy.ORCID 0000-0001-9555-1291
Giorgio MirraDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro, Italy.
Paola ScoccoSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy.ORCID 0000-0003-4506-967X
Alessia Di GiancamilloDepartment of Biomedical Sciences for Health, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy.ORCID 0000-0003-1674-3020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to statistics and future predictions, meat consumption will increase in the coming years. Considering both the environmental impact of intensive livestock farming and the importance of protecting animal welfare, the necessity of finding alternative strategies to satisfy the growing meat demand is compelling. Biotechnologies are responding to this demand by developing new strategies for producing meat in vitro. The manufacturing of cultured meat has faced criticism concerning, above all, the practical issues of culturing together different cell types typical of meat that are partly responsible for meat's organoleptic characteristics. Indeed, the existence of a cross talk between adipose and muscle cells has critical effects on the outcome of the co-culture, leading to a general inhibition of myogenesis in favor of adipogenic differentiation. This review aims to clarify the main mechanisms and the key molecules involved in this cross talk and provide an overview of the most recent and successful meat culture 3D strategies for overcoming this challenge, focusing on the approaches based on farm-animal-derived cells.

Indexed as

LivestockMeatAnimalsCell Physiological PhenomenaCoculture TechniquesMuscle Cellscells co-culturefarm-animal-derived cellshydrogelin vitro meatmuscle and adipose cell cross talkscaffold

Identifiers

PMID37047600
PMCPMC10095036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.