Evidence map›Paper›PMID 37047588›Full record

ArticleInternational journal of molecular sciences2023

A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity.

Praveen Praveen, Chao Wang, Thomas N G Handley, Hongkang Wu, Chrishan S Samuel, Ross A D Bathgate, Mohammed Akhter Hossain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Further Developments towards a Minimal Potent Derivative of Human Relaxin-2.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Praveen PraveenFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0001-9068-6357
Chao WangCardiovascular Disease Program, Monash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, VIC 3168, Australia.
Thomas N G HandleyFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
Hongkang WuFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3052, Australia.
Chrishan S SamuelCardiovascular Disease Program, Monash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0003-0295-4214
Ross A D BathgateDepartment of Biochemistry and Pharmacology, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-6301-861X
Mohammed Akhter HossainFlorey Department of Neuroscience and Mental, Florey Institute of Neuroscience and Mental Health, School of Chemistry, Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-9961-0006
The University of Melbourne · AUAustralian Regenerative Medicine Institute · AU

Funding

National Health and Medical Research Council GNT2001178, GNT2001027, GNT1135837
6 · The paper itself

Abstract

Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin's receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target for the treatment of fibrosis and related disorders, including heart failure. H2 relaxin has a complex two-chain structure (A and B) and three disulfide bridges. Our laboratory has recently developed B7-33 peptide, a single-chain agonist based on the B-chain of H2 relaxin. However, the peptide B7-33 has a short circulation time in vitro in serum (t

Indexed as

RelaxinAnimalsFibrosisHumansReceptors, G-Protein-CoupledStructure-Activity RelationshipReceptors, G-Protein-CoupledRelaxinB7-33H2 relaxinRXFP1structure-activity relationship (SAR)

Identifiers

PMID37047588
PMCPMC10094921
OpenAlexW4362582936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.