Evidence map›Paper›PMID 37047490›Full record

ArticleInternational journal of molecular sciences2023

Molecular Basis of Unequal Alternative Splicing of Human SCD5 and Its Alteration by Natural Genetic Variations.

Gabriella Orosz, Luca Szabó, Szanna Bereti, Veronika Zámbó, Miklós Csala, Éva Kereszturi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gabriella OroszDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.ORCID 0000-0002-2030-287X
Luca SzabóDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.ORCID 0000-0002-1907-9957
Szanna BeretiDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.
Veronika ZámbóDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.
Miklós CsalaDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.ORCID 0000-0002-3829-4361
Éva KereszturiDepartment of Molecular Biology, Semmelweis University, H-1085 Budapest, Hungary.ORCID 0000-0003-4778-3332
Semmelweis University · HU

Funding

Ministry of Innovation and Technology of Hungary TKP2021-EGA-24National Research, Development and Innovation Office FK138115National Research, Development and Innovation Office PD142709
6 · The paper itself

Abstract

Alternative splicing (AS) is a major means of post-transcriptional control of gene expression, and provides a dynamic versatility of protein isoforms. Cancer-related AS disorders have diagnostic, prognostic and therapeutic values. Changes in the expression and AS of human stearoyl-CoA desaturase-5 (SCD5) are promising specific tumor markers, although the transcript variants (TVs) of the gene have not yet been confirmed. Our in silico, in vitro and in vivo study focuses on the distribution of SCD5 TVs (A and B) in human tissues, the functionality of the relevant splice sites, and their modulation by certain single-nucleotide variations (SNVs). An order of magnitude higher

Indexed as

Alternative SplicingStearoyl-CoA DesaturaseHumansMutationProtein IsoformsRNA Splice SitesProtein IsoformsRNA Splice SitesSCD5 protein, humanStearoyl-CoA Desaturaseacceptor sitealternative splicingcancerdonor sitegenetic variationminigene assaySNVstearoyl-CoA desaturase-5transcript variant

Identifiers

PMID37047490
PMCPMC10095032
OpenAlexW4362466629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.