Evidence map›Paper›PMID 37047454›Full record

ArticleInternational journal of molecular sciences2023

Zirconia-Toughened Alumina Ceramic Wear Particles Do Not Elicit Inflammatory Responses in Human Macrophages.

Alessandro Alan Porporati, Yvonne Mödinger, Sarah Fischer, Sara Polajžer, Melanie Mettang, Ulrike Deisinger, Matejka Podlogar, Rihard Trebše, Nika Lovšin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Alessandro Alan PorporatiMedical Products Division, CeramTec GmbH, 73207 Plochingen, Germany.ORCID 0000-0003-1348-940X
Yvonne MödingerMedical Products Division, CeramTec GmbH, 73207 Plochingen, Germany.ORCID 0000-0001-9789-6189
Sarah FischerMedizintechnik, University of Stuttgart, 70174 Stuttgart, Germany.ORCID 0000-0001-8490-6579
Sara PolajžerFaculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.
Melanie MettangMedical Products Division, CeramTec GmbH, 73207 Plochingen, Germany.
Ulrike DeisingerMedical Products Division, CeramTec GmbH, 73207 Plochingen, Germany.
Matejka PodlogarJozef Stefan Institute, 1000 Ljubljana, Slovenia.
Rihard TrebšeValdoltra Orthopaedic Hospital, 6280 Ankaran, Slovenia.ORCID 0000-0002-1075-3351
Nika LovšinFaculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia.
CeramTec (Germany) · DEUniversity of Ljubljana · SIJožef Stefan Institute · SIUniversity of Stuttgart · DEUniversity of Trieste · IT

Funding

Slovenian Research Agency J3-2518; J3-1749; J3-1759; L3-3176; P4-0127; P3-0298
6 · The paper itself

Abstract

Ten percent of patients undergoing total hip arthroplasty (THA) require revision surgery. One of the reasons for THA are wear particles released from the implants that can activate the immune defense and cause osteolysis and failure of the joint implant. The discrepancies between reports on toxicity and immunogenicity of the implant materials led us to this study in which we compared toxicity and immunogenicity of well-defined nanoparticles from Al

Indexed as

Hip ProsthesisAluminum OxideCeramicsChromium AlloysHumansMacrophagesMaterials TestingZirconiumAluminum OxideChromium AlloysZirconiumzirconium oxidealuminacell viabilitycytokine secretioninflammationmacrophagesnanoparticlesorthopaedic implantzirconia-toughened alumina (ZTA)

Identifiers

PMID37047454
PMCPMC10095128
OpenAlexW4361275334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.