Evidence map›Paper›PMID 37047380›Full record

ArticleInternational journal of molecular sciences2023

Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics.

Yafeng Wang, Menglin Xue, Ruixuan Gao, Soumyadeep Chakraborty, Shaohui Wang, Xue Zhao, Meng Gu, Chuanhai Cao, Xingmin Sun, Jianfeng Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yafeng WangDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA.
Menglin XueDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA.
Ruixuan GaoDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA.
Soumyadeep ChakrabortyDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.ORCID 0000-0002-3882-7172
Shaohui WangDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Xue ZhaoDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Meng GuDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Chuanhai CaoCollege of Pharmacy, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Jianfeng CaiDepartment of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA.

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
Antimicrobial agents derived from AApeptide biomaterialsR01AI152416 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2020 to 2024
$1.9M
Effect of bile salt hydrolase inhibitors on Clostridium difficile infectionR21AI159745 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI LIN, JUN, SUN, XINGMIN · 2021 to 2022
$416k
NIAID NIH HHS R01 AI132711NIAID NIH HHS R01 AI149852NIAID NIH HHS R01 AI152416NIAID NIH HHS R21 AI159745NIH HHS NIH RO1AI152416, NIH RO1AI149852
6 · The paper itself

Abstract

Antibiotic resistance is one of the most significant issues encountered in global health. There is an urgent demand for the development of a new generation of antibiotic agents combating the emergence of drug resistance. In this article, we reported the design of lipidated dendrimeric γ-AApeptides as a new class of antimicrobial agents. These AApeptides showed excellent potency and broad-spectrum activity against both Gram-positive bacteria and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The mechanistic studies revealed that the dendrimeric AApeptides could kill bacteria rapidly through the permeabilization of bacterial membranes, analogous to host-defense peptides (HDPs). These dendrimers also did not induce antibiotic resistance readily. The easy access to the synthesis, together with their potent and broad-spectrum activity, make these lipidated dendrimeric γ-AApeptides a new generation of antibacterial agents.

Indexed as

Anti-Infective AgentsMethicillin-Resistant Staphylococcus aureusPeptidomimeticsAmidesAnti-Bacterial AgentsBacteriaMicrobial Sensitivity TestsAmidesAnti-Bacterial AgentsAnti-Infective Agentsgamma-AApeptidePeptidomimeticsantibiotic resistancebroad spectrum activitydendrimeric γ-AApeptides

Identifiers

PMID37047380
PMCPMC10094648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.