Evidence map›Paper›PMID 37047377›Full record

ReviewInternational journal of molecular sciences2023

Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update.

Riccardo Giorgino, Domenico Albano, Stefano Fusco, Giuseppe M Peretti, Laura Mangiavini, Carmelo Messina

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 238 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed, 18 pooled it
79.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06622512 nacompletednot on this mapstarted 2024, after this paper: background citation

Double-Blind Randomized Controlled Trial Comparing the Effectiveness of Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis.

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2024 to 2025Enrolled82ConditionsOsteoarthritis, KneeArmsRadial Pressure Wave Therapy
NCT07063953 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Egoscue Exercises on Pain, Range of Motion and Physical Function in Patients With Knee Osteoarthritis

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled42ConditionsKnee OsteoarthritisArmsStandard Physical Therapy, Egoscue Exercises
NCT07613749 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of mechanical traction applied before versus after therapeutic exercises on clinical and functional outcomes in primary knee osteoarthritis

TypeinterventionalSponsorCairo UniversityRan2026 to 2027Enrolled63ConditionsKnee Osteoarthritis, Mechanical TractionArmsGroup A: Therapeutic exercise group, Group B: mechanical traction followed by therapeutic exercise, Group C: therapeutic exercise followed by mechanical traction
3 · Its place in the literature

Who cites it

238 citing papers in PubMed, 18 syntheses or guidelines pooled it, 319 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Management of hip osteoarthritis: harnessing the potential of mesenchymal stem cells-a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Pooled it
  17. Pooled it
  18. Pooled it
  19. Trial
  20. Trial

178 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Riccardo GiorginoIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0002-1067-7424
Domenico AlbanoIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-7989-9861
Stefano FuscoPostgraduate School of Diagnostic and Interventional Radiology, University of Milan, 20141 Milan, Italy.
Giuseppe M PerettiIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-9341-7187
Laura MangiaviniIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Carmelo MessinaIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0001-7518-5773
University of Milan · ITIstituto Ortopedico Galeazzi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast majority of the social OA burden is related to hips and knees. The prevalence of knee OA varied across studies and such differences are reflected by the heterogeneity of data reported by studies conducted worldwide. A complete understanding of the pathogenetic mechanisms underlying this pathology is essential. The OA inflammatory process starts in the synovial membrane with the activation of the immune system, involving both humoral and cellular mediators. A crucial role in this process is played by the so-called "damage-associated molecular patterns" (DAMPs). Mesenchymal stem cells (MSCs) may be a promising option among all possible therapeutic options. However, many issues are still debated, such as the best cell source, their nature, and the right amount. Further studies are needed to clarify the remaining doubts. This review provides an overview of the most recent and relevant data on the molecular mechanism of cartilage damage in knee OA, including current therapeutic approaches in regenerative medicine.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoarthritis, KneeHumansSynovial Membranekneemesenchymal stem cellsosteoarthritispathogenesisregenerative medicine

Identifiers

PMID37047377
PMCPMC10094836
OpenAlexW4361305110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.