Evidence map›Paper›PMID 37047296›Full record

ArticleInternational journal of molecular sciences2023

Glyphosate and Aminomethylphosphonic Acid (AMPA) Modulate Glutathione S-Transferase in Non-Tumorigenic Prostate Cells.

Dayanne Silva Borges, Lara Vecchi, Deysse Carla Tolentino Barros, Vinícius Marques Arruda, Helen Soares Valença Ferreira, Matheus Fernandes da Silva, Joyce Ferreira da Costa Guerra, Raoni Pais Siqueira, Thaise Gonçalves Araújo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dayanne Silva BorgesLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Lara VecchiLaboratory of Nanobiotechnology Prof. Dr. Luiz Ricardo Goulart Filho, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil.
Deysse Carla Tolentino BarrosLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Vinícius Marques ArrudaLaboratory of Biochemistry, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Helen Soares Valença FerreiraLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Matheus Fernandes da SilvaLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.ORCID 0000-0001-9356-9439
Joyce Ferreira da Costa GuerraLaboratory of Biochemistry, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Raoni Pais SiqueiraLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.
Thaise Gonçalves AraújoLaboratory of Genetics and Biotechnology, Institute of Biotechnology, Federal University of Uberlandia, Patos de Minas 38700-002, MG, Brazil.ORCID 0000-0002-7593-1403
Universidade Federal de Uberlândia · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00760-18 and REMITRIBIC RED-00031-21
6 · The paper itself

Abstract

Glyphosate (GLY) was developed in the early 1970s and has become the most used broad-spectrum herbicide in the world so far. Its main metabolite is aminomethylphosphonic acid (AMPA), and the accumulation of GLY and its derivative compounds raises some concerns regarding possible health outcomes. In this study, we aimed to evaluate the effects of GLY and AMPA on prostate cell lines by evaluating cell viability, proliferation, gene and protein expression, and cellular pathways involved in the response to oxidative stress. Our results indicated that GLY and AMPA reduced the cell viability of tumorigenic and non-tumorigenic prostate cell lines only at higher concentrations (10 mM GLY and 20 mM AMPA). In contrast, both compounds increased the clonogenicity of non-tumorigenic PNT2 cells, mainly at concentrations below the IC

Indexed as

Glutathione TransferaseHerbicidesalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidGlyphosateHumansMaleOrganophosphonatesOrganophosphorus CompoundsProstateTetrazoles1-aminomethylphosphonic acidalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acidaminomethylphosphonic acid (AMPA)Glutathione TransferaseGlyphosateHerbicidesOrganophosphonatesOrganophosphorus CompoundsTetrazolesaminomethylphosphonic acidglyphosatemetabolismorganophosphateprostatetranscripts

Identifiers

PMID37047296
PMCPMC10094733
OpenAlexW4361208616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.