Evidence map›Paper›PMID 37047230›Full record

ArticleInternational journal of molecular sciences2023

Crystal Structure of Pyrrolysyl-tRNA Synthetase from a Methanogenic Archaeon ISO4-G1 and Its Structure-Based Engineering for Highly-Productive Cell-Free Genetic Code Expansion with Non-Canonical Amino Acids.

Tatsuo Yanagisawa, Eiko Seki, Hiroaki Tanabe, Yoshifumi Fujii, Kensaku Sakamoto, Shigeyuki Yokoyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. BeyondChemical reviews · 2025
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tatsuo YanagisawaRIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.
Eiko SekiRIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.
Hiroaki TanabeRIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.
Yoshifumi FujiiRIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.
Kensaku SakamotoRIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.ORCID 0000-0003-2866-5031
Shigeyuki YokoyamaRIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-Cho, Tsurumi, Yokohama 230-0045, Japan.ORCID 0000-0003-3133-7338
RIKEN Center for Sustainable Resource Science · JPRIKEN Center for Biosystems Dynamics Research · JP

Funding

Japan Agency for Medical Research and Development Leading Advanced Projects for Medical Innovation (LEAP) under Grant Number JP19gm0010001Japan Agency for Medical Research and Development The Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Sup-porting Innovative Drug Discovery and Life Science Research (BINDS)) under Grant Number JP17am0101081Ministry of Education, Culture, Sports, Science and Technology 16K05859Ministry of Education, Culture, Sports, Science and Technology 24550203Takeda Science Foundation N/A
6 · The paper itself

Abstract

Pairs of pyrrolysyl-tRNA synthetase (PylRS) and tRNA

Indexed as

Amino Acyl-tRNA SynthetasesAmino AcidsGenetic CodeLysineMethanosarcinaRNA, TransferAmino AcidsAmino Acyl-tRNA SynthetasesLysineRNA, Transfercell-free protein synthesiscrystal structuregenetic code expansionnon-canonical amino acidstRNA

Identifiers

PMID37047230
PMCPMC10094482
OpenAlexW4361007124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.