ArticleInternational journal of molecular sciences2023
H3K4me1 Modification Functions in Caste Differentiation in Honey Bees.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- ACmix-Swin Deep Learning of 4-Day-OldGenes · 2025Article
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- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera).Genome biology · 2025Article
- The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution.Non-coding RNA research · 2025Review
- Chinese sacbrood virus mediates m6A modification to target and suppress the expression of hemolymph maintenance gene AF9, exacerbating bee infections.Journal of virology · 2025Article
- Article
- Epigenetics Mechanisms of Honeybees: Secrets of Royal Jelly.Epigenetics insights · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Honey bees are important species for the study of epigenetics. Female honey bee larvae with the same genotype can develop into phenotypically distinct organisms (sterile workers and fertile queens) depending on conditions such as diet. Previous studies have shown that DNA methylation and histone modification can establish distinct gene expression patterns, leading to caste differentiation. It is unclear whether the histone methylation modification H3K4me1 can also impact caste differentiation. In this study, we analyzed genome-wide H3K4me1 modifications in both queen and worker larvae and found that H3K4me1 marks are more abundant in worker larvae than in queen larvae at both the second and fourth instars, and many genes associated with caste differentiation are differentially methylated. Notably, caste-specific H3K4me1 in promoter regions can direct worker development. Thus, our results suggest that H3K4me1 modification may act as an important regulatory factor in the establishment and maintenance of caste-specific transcriptional programs in honey bees; however, the potential influence of other epigenetic modifications cannot be excluded.
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