Evidence map›Paper›PMID 37047128›Full record

ArticleInternational journal of molecular sciences2023

Med25 Limits Master Regulators That Govern Adipogenesis.

Jasmine Saunders, Kunal Sikder, Elizabeth Phillips, Anurag Ishwar, David Mothy, Kenneth B Margulies, Jason C Choi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. CORN 2.0 - Condition Orientated Regulatory Networks 2.0.Computational and structural biotechnology journal · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jasmine SaundersCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Kunal SikderCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Elizabeth PhillipsCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Anurag IshwarCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
David MothyCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-0583-4058
Kenneth B MarguliesCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jason C ChoiCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Funding

Cell type-specific function of LMNA during myocardial stress in the development of cardiomyopathyR01HL150019 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2020 to 2023
$1.6M
Dusp4 in the pathogenesis of LMNA cardiomyopathyR00HL118163 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2016 to 2018
$737k
NHLBI NIH HHS R00 HL118163NHLBI NIH HHS R01 HL150019NIH HHS R01HL150019 and R00HL118163
6 · The paper itself

Abstract

Mediator 25 (Med25) is a member of the mediator complex that relays signals from transcription factors to the RNA polymerase II machinery. Multiple transcription factors, particularly those involved in lipid metabolism, utilize the mediator complex, but how Med25 is involved in this context is unclear. We previously identified Med25 in a translatome screen of adult cardiomyocytes (CMs) in a novel cell type-specific model of

Indexed as

AdipogenesisLamin Type A3T3-L1 CellsAnimalsCell DifferentiationLipidsMediator ComplexMicePPAR gammaTranscription FactorsLamin Type ALipidsMed25 protein, mouseMediator ComplexPPAR gammaTranscription Factorsadipogenesislipid accumulationLMNAmediator complex

Identifiers

PMID37047128
PMCPMC10093881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.