Evidence map›Paper›PMID 37047078›Full record

ArticleInternational journal of molecular sciences2023

Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model.

Ivana F Rosa, Ana P B Peçanha, Tábata R B Carvalho, Leonardo S Alexandre, Vinícius G Ferreira, Lucas B Doretto, Beatriz M Souza, Rafael T Nakajima, Patrick da Silva, Ana P Barbosa and 32 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 13 institutions in 2 countries.

Ivana F RosaDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.ORCID 0000-0002-6128-0099
Ana P B PeçanhaDepartment of Orthodontics, São Leopoldo Mandic College, Campinas 13045-755, Brazil.
Tábata R B CarvalhoDepartment of Orthodontics, São Leopoldo Mandic College, Campinas 13045-755, Brazil.
Leonardo S AlexandreInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, Brazil.
Vinícius G FerreiraInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, Brazil.
Lucas B DorettoDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.
Beatriz M SouzaDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.
Rafael T NakajimaDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.ORCID 0000-0002-9931-1102
Patrick da SilvaInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0002-3481-4972
Ana P BarbosaInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0003-0045-6828
Leticia Gomes-de-PontesInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0002-6648-3880
Camila G BomfimInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0002-7367-2153
Glaucia M Machado-SantelliInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0003-2046-9693
Antonio Condino-NetoInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.
Cristiane R GuzzoInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0002-5664-8055
Jean P S PeronInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0003-1638-8866
Magaiver Andrade-SilvaInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.
Niels O S CâmaraInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.ORCID 0000-0001-5436-1248
Anali M B GarniqueInstitute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-220, Brazil.
Renata J MedeirosOswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.ORCID 0000-0003-2991-1265
Fausto K FerrarisOswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.ORCID 0000-0001-9434-3503
Leonardo J G BarcellosLaboratório de Fisiologia de Peixes, Programa de Pós-Graduação em Bioexperimentação, Escola de Ciências Agrárias, Inovação e Negócios, Universidade de Passo Fundo, Passo Fundo 99052-900, Brazil.
Jose D Correia-JuniorInstitute of Biomedical Sciences, Federal University Minas Gerais, Belo Horizonte 31270-901, Brazil.ORCID 0000-0002-8623-8524
Jorge Galindo-VillegasDepartment of Genomics, Faculty of Biosciences and Aquaculture, Nord University, 8026 Bodø, Norway.ORCID 0000-0002-4250-2477
Mônica F R MachadoBiological Sciences Special Academic Unit, Federal University of Jatai, Jatai 75804-020, Brazil.
Angela CastoldiKeizo Asami Institute, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-8434-7989
Susana L OliveiraSchool of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, Brazil.
Camila C CostaSchool of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, Brazil.
Marco A A BeloSchool of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal 14884-900, Brazil.
Giovane GaldinoInstitute of Motricity Sciences, Department of Physical Therapy, Federal University of Alfenas, Alfenas 37133-840, Brazil.
Germán G SgroDepartamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo 14040-900, Brazil.ORCID 0000-0002-2831-7945
Natalia F BuenoIntegrated Structural Biology Platform, Carlos Chagas Institute, FIOCRUZ Paraná, Curitiba 81310-020, Brazil.
Silas F EtoCenter of Innovation and Development, Laboratory of Development and Innovation Butantan Institute, São Paulo 69310-000, Brazil.ORCID 0000-0003-4796-9727
Flávio P VerasFaculty of Medicine, University of São Paulo (USP), Ribeirão Preto 14040-900, Brazil.
Bianca H V FernandesLaboratory of Genetic and Sanitary Control, Technical Board of Support for Teaching and Research, Faculty of Medicine, University of Sao Paulo, São Paulo 01246-903, Brazil.ORCID 0000-0002-2213-4355
Paulo R S SanchesDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, Brazil.
Eduardo M CilliDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, Brazil.ORCID 0000-0002-4767-0904
Guilherme MalafaiaLaboratory of Toxicology Applied to the Environment, Goiano Federal Institute, Urutaí Campus, Urutaí 75790-000, Brazil.
Rafael H NóbregaDepartment of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu 01049-010, Brazil.ORCID 0000-0001-9796-5076
Aguinaldo S GarcezDepartment of Orthodontics, São Leopoldo Mandic College, Campinas 13045-755, Brazil.
Emanuel CarrilhoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, Brazil.ORCID 0000-0001-7351-8220
Ives Charlie-SilvaDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-060, Brazil.
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRFaculdade São Leopoldo Mandic · BRFundação Oswaldo Cruz · BRFundação Carlos Chagas · BRInstituto Butantan · BRInstituto Federal Goiano · BRNord University · NOUniversidade de Passo Fundo · BRUniversidade Federal de Alfenas · BRUniversidade Federal de Jataí · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de Pernambuco · BR

Funding

São Paulo Research Foundation 20/15237-0
6 · The paper itself

Abstract

Although the exact mechanism of the pathogenesis of coronavirus SARS-CoV-2 (COVID-19) is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role in the pathogenesis of the disease. In this sense, alternative treatments are needed to reduce the level of inflammation caused by COVID-19. Therefore, this study aimed to investigate the potential effect of red photobiomodulation (PBM) as an attractive therapy to downregulate the cytokine storm caused by COVID-19 in a zebrafish model. RT-qPCR analyses and protein-protein interaction prediction among SARS-CoV-2 and

Indexed as

COVID-19AnimalsCytokine Release SyndromeCytokinesHumansMembrane ProteinsMitochondrial ProteinsRNA, MessengerSARS-CoV-2ZebrafishCytokinesMembrane ProteinsMitochondrial ProteinsRNA, MessengerROMO1 protein, humanCOVID-19cytokine stormsoxidative stressphotobiomodulationrSpikezebrafish

Identifiers

PMID37047078
PMCPMC10094635
OpenAlexW4360860200

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.