Evidence map›Paper›PMID 37047048›Full record

ArticleInternational journal of molecular sciences2023

MPEP Attenuates Intrahepatic Fat Accumulation in Obese Mice.

Andrea Ferrigno, Marta Cagna, Oriana Bosco, Michelangelo Trucchi, Clarissa Berardo, Ferdinando Nicoletti, Mariapia Vairetti, Laura G Di Pasqua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andrea FerrignoUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-2337-2897
Marta CagnaUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-3942-421X
Oriana BoscoUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Michelangelo TrucchiUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
Clarissa BerardoDepartment of Biomedical and Clinical Science, University of Milano, 20157 Milano, Italy.ORCID 0000-0002-1257-5843
Ferdinando NicolettiDepartment of Physiology and Pharmacology, Sapienza University, 00185 Rome, Italy.
Mariapia VairettiUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2464-6127
Laura G Di PasquaUnit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-0103-1493
University of Pavia · ITIstituto Neurologico Mediterraneo · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blockade of metabotropic glutamate receptor type 5 (mGluR5) was previously found to reduce fat accumulation in HEPG2 cells. Here, we evaluated the effects of mGluR5 blockade in a mouse model of steatosis. Male

Indexed as

Fatty LiverNon-alcoholic Fatty Liver DiseaseAnimalsDiet, High-FatDisease Models, AnimalLiverMaleMiceMice, Inbred C57BLMice, ObeseNF-kappa BPPAR alphaSterol Regulatory Element Binding Protein 1TOR Serine-Threonine KinasesNF-kappa BPPAR alphaSterol Regulatory Element Binding Protein 1TOR Serine-Threonine Kinaseshigh-fat dietlivermGluR5MPEPNAFLDNASHob/ob mice

Identifiers

PMID37047048
PMCPMC10094379
OpenAlexW4360861193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.