Evidence map›Paper›PMID 37047028›Full record

ReviewInternational journal of molecular sciences2023

Tissue Engineering Challenges for Cultivated Meat to Meet the Real Demand of a Global Market.

Andressa Cristina Antunes Santos, Denisse Esther Mallaupoma Camarena, Gustavo Roncoli Reigado, Felipe S Chambergo, Viviane Abreu Nunes, Marco Antonio Trindade, Silvya Stuchi Maria-Engler

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Bioprocess Engineering for Cultivated Meat.Advances in biochemical engineering/biotechnology · 2026
    Review
  9. Compression bioreactor for cultured meat.Current research in food science · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Functional expression and secretion of basic fibroblast growth factor inFrontiers in bioengineering and biotechnology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andressa Cristina Antunes SantosDepartment of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Denisse Esther Mallaupoma CamarenaDepartment of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-3989-7612
Gustavo Roncoli ReigadoDepartment of Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.
Felipe S ChambergoDepartment of Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.ORCID 0000-0001-7567-0656
Viviane Abreu NunesDepartment of Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.
Marco Antonio TrindadeFaculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque de Caxias Norte, Pirassununga 13635-900, Brazil.
Silvya Stuchi Maria-EnglerDepartment of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-4771-6041

Funding

CNPq Fellowship 309440/2021-1FUSP NAGOSTOSISSIMI COMÉRCIO DE ALIMENTOS LTDA NA
6 · The paper itself

Abstract

Cultivated meat (CM) technology has the potential to disrupt the food industry-indeed, it is already an inevitable reality. This new technology is an alternative to solve the environmental, health and ethical issues associated with the demand for meat products. The global market longs for biotechnological improvements for the CM production chain. CM, also known as cultured, cell-based, lab-grown, in vitro or clean meat, is obtained through cellular agriculture, which is based on applying tissue engineering principles. In practice, it is first necessary to choose the best cell source and type, and then to furnish the necessary nutrients, growth factors and signalling molecules via cultivation media. This procedure occurs in a controlled environment that provides the surfaces necessary for anchor-dependent cells and offers microcarriers and scaffolds that favour the three-dimensional (3D) organisation of multiple cell types. In this review, we discuss relevant information to CM production, including the cultivation process, cell sources, medium requirements, the main obstacles to CM production (consumer acceptance, scalability, safety and reproducibility), the technological aspects of 3D models (biomaterials, microcarriers and scaffolds) and assembly methods (cell layering, spinning and 3D bioprinting). We also provide an outlook on the global CM market. Our review brings a broad overview of the CM field, providing an update for everyone interested in the topic, which is especially important because CM is a multidisciplinary technology.

Indexed as

Meat ProductsTissue EngineeringBiotechnologyMeatReproducibility of ResultsTissue Scaffolds3D modelsanimal-free mediumassembly methodsbiotechnologicalscaffolds

Identifiers

PMID37047028
PMCPMC10094385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.