Evidence map›Paper›PMID 37047007›Full record

ArticleInternational journal of molecular sciences2023

Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives.

Cheng-Yao Yang, Min-Yu Lee, Yeh-Long Chen, Jun-Ping Shiau, Yung-Hsiang Tsai, Chia-Ning Yang, Hsueh-Wei Chang, Chih-Hua Tseng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Cheng-Yao YangDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.
Min-Yu LeeGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yeh-Long ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.
Jun-Ping ShiauDivision of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yung-Hsiang TsaiDepartment of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811213, Taiwan.ORCID 0000-0003-2992-7101
Chia-Ning YangInstitute of Precision Medicine, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Hsueh-Wei ChangDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-0068-2366
Chih-Hua TsengDepartment of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.ORCID 0000-0001-7392-7104
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWNational Kaohsiung Marine University · TW

Funding

Kaohsiung Medical University M111005, 110KK008, 111KK017Ministry of Science and Technology MOST 111-2320-B-037-021-MY3,
6 · The paper itself

Abstract

A series of 4-anilinoquinolinylchalcone derivatives were synthesized and evaluated for antiproliferative activities against the growth of human cancer cell lines (Huh-7 and MDA-MB-231) and normal lung cells (MRC-5). The results exhibited low cytotoxicity against human lung cells (MRC-5). Among them, (

Indexed as

Antineoplastic AgentsBreast NeoplasmsApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorFemaleHumansMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsReactive Oxygen Species4-anilinoquinolinylchalconeapoptosiscytotoxicitylapatinibreactive oxygen species

Identifiers

PMID37047007
PMCPMC10094048
OpenAlexW4360616191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.