Evidence map›Paper›PMID 37046870›Full record

ArticleHealthcare (Basel, Switzerland)2023

Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19.

Ahmed M E Elkhalifa, Naveed Nazir Shah, Zaid Khan, Sofi Imtiyaz Ali, Showkat Ul Nabi, Showkeen Muzamil Bashir, Masood Saleem Mir, Elsharif A Bazie, Abozer Y Elderdery, Awadh Alanazi and 2 more

Abstract read
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In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmed M E ElkhalifaDepartment of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh 11673, Saudi Arabia.ORCID 0000-0002-2660-5054
Naveed Nazir ShahDepartment of Chest Medicine, Government Medical College, Srinagar 191202, Jammu & Kashmir, India.ORCID 0000-0002-9486-6715
Zaid KhanDepartment of Chest Medicine, Government Medical College, Srinagar 191202, Jammu & Kashmir, India.
Sofi Imtiyaz AliBiochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences (F.V.Sc.) and Animal Husbandry (A.H), SKUAST-K, Shuhama, Alusteng, Srinagar 190006, Jammu & Kashmir, India.ORCID 0000-0002-3439-5894
Showkat Ul NabiLarge Animal Diagnostic Laboratory, Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Faculty of Veterinary Sciences (F.V.Sc.) and Animal Husbandry (A.H), SKUAST-K, Shuhama, Alusteng, Srinagar 190006, Jammu & Kashmir, India.ORCID 0000-0001-9091-7696
Showkeen Muzamil BashirBiochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences (F.V.Sc.) and Animal Husbandry (A.H), SKUAST-K, Shuhama, Alusteng, Srinagar 190006, Jammu & Kashmir, India.
Masood Saleem MirDepartment of Veterinary Pathology, Faculty of Veterinary Sciences (F.V.Sc.) and Animal Husbandry (A.H), SKUAST-K, Shuhama, Alusteng, Srinagar 190006, Jammu & Kashmir, India.
Elsharif A BaziePediatric Department, Faculty of Medicine University of El Imam El Mahdi, Kosti 1158, Sudan.ORCID 0000-0002-5213-564X
Abozer Y ElderderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0002-6219-5312
Awadh AlanaziDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0002-6750-4815
Fawaz O AlenazyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0002-2860-5509
Elsadig Mohamed AhmedDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, P.O. Box 551, Bisha 61922, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study evaluated the clinical presentation and outcome of COVID-19 patients with underlying hypercreatinemia at the time of hospitalization. A retrospective observational study was conducted from the 23rd of March 2020 to the 15th of April 2021 in 1668 patients confirmed positive for COVID-19 in the Chest Disease Hospital in Srinagar, India. The results of the present study revealed that out of 1668 patients, 339 with hypercreatinemia had significantly higher rates of admission to the intensive care unit (ICU), severe manifestations of the disease, need for mechanical ventilation, and all-cause mortality. Multivariable analysis revealed that age, elevated creatinine concentrations, IL-1, D-Dimer, and Hs-Crp were independent risk factors for in-hospital mortality. After adjusted analysis, the association of creatinine levels remained strongly predictive of all-cause, in-hospital mortality (HR-5.34; CI-4.89-8.17;

Indexed as

COVID-19hypercreatinemicintensive caremechanical ventilationoutcome

Identifiers

PMID37046870
PMCPMC10094500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.