Evidence map›Paper›PMID 37046778›Full record

ArticleCancers2023

Pretreatment Plasma Circulating Tumor DNA RAS/BRAF Mutational Status in Refractory Metastatic Colorectal Cancer Patients Who Are Candidates for Anti-EGFR Rechallenge Therapy: A Pooled Analysis of the CAVE and VELO Clinical Trials.

Davide Ciardiello, Stefania Napolitano, Vincenzo Famiglietti, Lucia Esposito, Vincenzo De Falco, Alessandra Di Liello, Antonio Avallone, Evaristo Maiello, Filippo Pietrantonio, Chiara Cremolini and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Davide CiardielloMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Stefania NapolitanoMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Vincenzo FamigliettiMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Lucia EspositoMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Vincenzo De FalcoMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0003-0261-0382
Alessandra Di LielloMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Antonio AvalloneExperimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori, IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0001-6188-5664
Evaristo MaielloOncology Unit, IRCCS Foundation Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-3890-3435
Filippo PietrantonioMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0002-8530-8420
Chiara CremoliniUnit of Medical Oncology 2, University Hospital of Pisa, 56126 Pisa, Italy.
Maria Giulia ZampinoDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, 20141 Milan, Italy.
Nicola FazioDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, 20141 Milan, Italy.ORCID 0000-0001-6869-0704
Teresa TroianiMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Erika MartinelliMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Fortunato CiardielloMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giulia MartiniMedical Oncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0003-4093-2681
University of Campania "Luigi Vanvitelli" · ITEuropean Institute of Oncology · ITCasa Sollievo della Sofferenza · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Pisa · IT

Funding

Regione Campania Cup 21C17000030007
6 · The paper itself

Abstract

Rechallenge with anti-EGFR drugs represents a promising strategy in refractory

Indexed as

anti-EGFR drugsliquid biopsymetastatic colorectal cancerrechallenge therapy

Identifiers

PMID37046778
PMCPMC10093522
OpenAlexW4362584062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.