Evidence map›Paper›PMID 37046768›Full record

ArticleCancers2023

Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential.

Nathalie S M Lak, Anne Seijger, Lieke M J van Zogchel, Nina U Gelineau, Ahmad Javadi, Lily Zappeij-Kannegieter, Laura Bongiovanni, Anneloes Andriessen, Janine Stutterheim, C Ellen van der Schoot and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Nathalie S M LakPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
Anne SeijgerDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Lieke M J van ZogchelPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0003-3557-7195
Nina U GelineauPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
Ahmad JavadiDepartment of Experimental Immunohematology, Sanquin Research, 1066 CX Amsterdam, The Netherlands.
Lily Zappeij-KannegieterDepartment of Experimental Immunohematology, Sanquin Research, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-5493-5149
Laura BongiovanniDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.ORCID 0000-0001-8942-6048
Anneloes AndriessenDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Janine StutterheimPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
C Ellen van der SchootDepartment of Experimental Immunohematology, Sanquin Research, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0002-8065-3540
Alain de BruinDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Godelieve A M TytgatPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
Sanquin · NLUtrecht University · NLPrincess Máxima Center · NLUniversity of Teramo · IT

Funding

Foundation KiKa 312
6 · The paper itself

Abstract

Neuroblastoma affects mostly young children, bearing a high morbidity and mortality. Liquid biopsies, e.g., molecular analysis of circulating tumor-derived nucleic acids in blood, offer a minimally invasive diagnostic modality. Cell-free RNA (cfRNA) is released by all cells, especially cancer. It circulates in blood packed in extracellular vesicles (EV) or attached to proteins. We studied the feasibility of analyzing cfRNA and EV, isolated by size exclusion chromatography (SEC), from platelet-poor plasma from healthy controls (

Indexed as

cell-free RNAextracellular vesiclesliquid biopsiesneuroblastomapediatricsolid tumors

Identifiers

PMID37046768
PMCPMC10093559
OpenAlexW4362577869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.