Evidence map›Paper›PMID 37046732›Full record

ArticleCancers2023

KRAS Mutations Are Associated with Shortened Survival in Patients with Epithelioid Malignant Pleural Mesothelioma.

Margherita Vannucchi, Veronica Pennati, Clelia Mencaroni, Chiara Defraia, Ledi Bardhi, Francesca Castiglione, Cristiana Bellan, Camilla Eva Comin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Margherita VannucchiSection of Pathology, Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Veronica PennatiDivision of Pathological anatomy, Department of Medical and Surgical Critical Care, University of Florence, 50121 Florence, Italy.
Clelia MencaroniDivision of Pathological anatomy, Department of Medical and Surgical Critical Care, University of Florence, 50121 Florence, Italy.
Chiara DefraiaSection of Pathology, Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy.
Ledi BardhiSection of Pathology, Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0009-0001-5946-8631
Francesca CastiglioneDivision of Pathological anatomy, Department of Medical and Surgical Critical Care, University of Florence, 50121 Florence, Italy.
Cristiana BellanSection of Pathology, Department of Medical Biotechnology, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6119-9007
Camilla Eva CominDepartment of Experimental and Clinical Medicine, Section of Surgery, Histopathology and Molecular Pathology, University of Florence, 50121 Florence, Italy.
University of Florence · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleural surface that includes three major histologic subtypes, epitheliod, sarcomatoid and biphasic. Epithelioid mesothelioma is usually associated with better prognosis. The genetic mechanisms driving MPM, the possible target mutations and the correlation with overall survival remain largely unsettled. We performed target exome sequencing in 29 cases of MPM aimed at identifying somatic mutations and, eventually, their correlation with phenotypic traits and prognostic significance. We found that

Indexed as

epithelioid mesotheliomaKDR geneKRAS mutationMPM prognosispleural mesothelioma

Identifiers

PMID37046732
PMCPMC10093256
OpenAlexW4362519955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.