Evidence map›Paper›PMID 37046583›Full record

ArticleCancers2023

Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model.

Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L Harris, Aye Aye Thike, Puay Hoon Tan and 2 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Soumya GhoseGE Research Center, Niskayuna, NY 12309, USA.
Sanghee ChoGE Research Center, Niskayuna, NY 12309, USA.ORCID 0000-0001-6715-9348
Fiona GintyGE Research Center, Niskayuna, NY 12309, USA.
Elizabeth McDonoughGE Research Center, Niskayuna, NY 12309, USA.
Cynthia DavisGE Research Center, Niskayuna, NY 12309, USA.
Zhanpan ZhangGE Research Center, Niskayuna, NY 12309, USA.
Jhimli MitraGE Research Center, Niskayuna, NY 12309, USA.ORCID 0000-0002-2347-7210
Adrian L HarrisDepartment of Oncology, Cancer and Haematology Centre, Oxford University, Oxford OX3 9DU, UK.ORCID 0000-0003-1376-8409
Aye Aye ThikeAnatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore.
Puay Hoon TanAnatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore.
Yesim Gökmen-PolarDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-9927-4893
Sunil S BadveDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-8861-9980

Funding

(PQC3) Ethnicity-determined immune response and DCIS outcomeR01CA194600 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BADVE, SUNIL S., GINTY, FIONA · 2015 to 2019
$2.7M
NCI NIH HHS R01 CA194600
6 · The paper itself

Abstract

Standard clinicopathological parameters (age, growth pattern, tumor size, margin status, and grade) have been shown to have limited value in predicting recurrence in ductal carcinoma in situ (DCIS) patients. Early and accurate recurrence prediction would facilitate a more aggressive treatment policy for high-risk patients (mastectomy or adjuvant radiation therapy), and simultaneously reduce over-treatment of low-risk patients. Generative adversarial networks (GAN) are a class of DL models in which two adversarial neural networks, generator and discriminator, compete with each other to generate high quality images. In this work, we have developed a deep learning (DL) classification network that predicts breast cancer events (BCEs) in DCIS patients using hematoxylin and eosin (H & E) images. The DL classification model was trained on 67 patients using image patches from the actual DCIS cores and GAN generated image patches to predict breast cancer events (BCEs). The hold-out validation dataset (

Indexed as

breast cancer eventsDCISdeep learningrisk-stratification

Identifiers

PMID37046583
PMCPMC10093091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.