ArticleDiagnostics (Basel, Switzerland)2023
Altered Functional Brain Network Structure between Patients with High and Low Generalized Anxiety Disorder.
Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Recent applications of EEG-based brain-computer-interface in the medical field.Military Medical Research · 2025Review
- Effect of music therapy on short-term psychological and physiological outcomes in mechanically ventilated patients: A randomized clinical pilot study.Journal of intensive medicine · 2024Article
- Integrating EEG and Ensemble Learning for Accurate Grading and Quantification of Generalized Anxiety Disorder: A Novel Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Article
- Neuroimaging Study of Brain Functional Differences in Generalized Anxiety Disorder and Depressive Disorder.Brain sciences · 2023Article
- Enhancing generalized anxiety disorder diagnosis precision: MSTCNN model utilizing high-frequency EEG signals.Frontiers in psychiatry · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To investigate the differences in functional brain network structures between patients with a high level of generalized anxiety disorder (HGAD) and those with a low level of generalized anxiety disorder (LGAD), a resting-state electroencephalogram (EEG) was recorded in 30 LGAD patients and 21 HGAD patients. Functional connectivity between all pairs of brain regions was determined by the Phase Lag Index (PLI) to construct a functional brain network. Then, the characteristic path length, clustering coefficient, and small world were calculated to estimate functional brain network structures. The results showed that the PLI values of HGAD were significantly increased in alpha2, and significantly decreased in the theta and alpha1 rhythms, and the small-world attributes for both HGAD patients and LGAD patients were less than one for all the rhythms. Moreover, the small-world values of HGAD were significantly lower than those of LGAD in the theta and alpha2 rhythms, which indicated that the brain functional network structure would deteriorate with the increase in generalized anxiety disorder (GAD) severity. Our findings may play a role in the development and understanding of LGAD and HGAD to determine whether interventions that target these brain changes may be effective in treating GAD.
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Registered trials
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