Evidence map›Paper›PMID 37046506›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Pre-Analytical Evaluation of Streck Cell-Free DNA Blood Collection Tubes for Liquid Profiling in Oncology.

Inga Medina Diaz, Annette Nocon, Stefanie A E Held, Makbule Kobilay, Dirk Skowasch, Abel J Bronkhorst, Vida Ungerer, Johannes Fredebohm, Frank Diehl, Stefan Holdenrieder and 1 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Inga Medina DiazResearch and Development, Sysmex Inostics GmbH, 20251 Hamburg, Germany.
Annette NoconResearch and Development, Sysmex Inostics GmbH, 20251 Hamburg, Germany.
Stefanie A E HeldDepartment of Hematology and Oncology, University Hospital, 53127 Bonn, Germany.
Makbule KobilayInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, 53127 Bonn, Germany.
Dirk SkowaschDepartment of Pneumology, University Hospital, 53127 Bonn, Germany.
Abel J BronkhorstGerman Heart Centre Munich, Institute for Laboratory Medicine, Technical University, 80636 Munich, Germany.
Vida UngererGerman Heart Centre Munich, Institute for Laboratory Medicine, Technical University, 80636 Munich, Germany.
Johannes FredebohmResearch and Development, Sysmex Inostics GmbH, 20251 Hamburg, Germany.
Frank DiehlResearch and Development, Sysmex Inostics GmbH, 20251 Hamburg, Germany.
Stefan HoldenriederInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, 53127 Bonn, Germany.ORCID 0000-0001-9210-7064
Frank HoltrupResearch and Development, Sysmex Inostics GmbH, 20251 Hamburg, Germany.
Sysmex (Germany) · DEUniversity Hospital Bonn · DEDeutsches Herzzentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excellent pre-analytical stability is an essential precondition for reliable molecular profiling of circulating tumor DNA (ctDNA) in oncological diagnostics. Therefore, in vitro degradation of ctDNA and the additional release of contaminating genomic DNA from lysed blood cells must be prevented. Streck Cell-Free DNA blood collection tubes (cfDNA BCTs) have proposed advantages over standard K

Indexed as

cell-free DNA (cfDNA)circulating tumor DNA (ctDNA)liquid profilingpre-analyticsprecision medicine

Identifiers

PMID37046506
PMCPMC10093569
OpenAlexW4361280469

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.