ArticleDiagnostics (Basel, Switzerland)2023
Idiopathic Pulmonary Hemorrhage in Infancy: A Case Report and Literature Review.
Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for pulmonary hemorrhage of very low birth weight infants: a meta-analysis.Italian journal of pediatrics · 2026Pooled it
- The Critical Importance of Autopsy in Diagnosing Acute Idiopathic Pulmonary Hemorrhage of Infancy.Case reports in pediatrics · 2026Article
- Leveraging artificial intelligence for prediction of pulmonary hemorrhage in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Evaluation of Apoptotic Caspase-3 Immunopositivity in Human Model of Asphyxial Death.International journal of molecular sciences · 2025Article
- Sudden Death: A Practical Autopsy Approach to Unexplained Mediastinitis Due to Fatal Untreated Neck Infections-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Traumatic Aneurysm Involving the Posterior Communicating Artery.Healthcare (Basel, Switzerland) · 2024Article
- Interstitial Lung Disease in Neonates: A Long Road Is Being Paved.Children (Basel, Switzerland) · 2023Article
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9 authors.
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Abstract
Acute idiopathic pulmonary hemorrhage in infants (AIPHI) is a rare and quite low-described entity. Nowadays, pathophysiological mechanisms are poorly understood, although the lethality remains high. We present an autopsy case report of a 2-day-old male who developed respiratory distress and blood leakage from the endotracheal tube (ET) and suddenly died because of acute pulmonary hemorrhage. A postmortem examination and histological analysis were performed and are reported in this paper. Alveolar spaces were filled with red blood cells and hyaline membranes in all the examined samples. The absence of other findings led us to select a post-mortem diagnosis of AIPHI. To support our diagnosis, we conducted a systematic review of the updated scientific literature and found that only 61 cases have been reported. Most of them presented acute respiratory distress and bleeding from the upper airways with blood leakage from ET (9.83%), hemoptysis (52.45%), epistaxis (8.2%), and hematemesis (3.27%). The autopsy data revealed hemorrhages of the lower airways and hemosiderin-laden macrophages. The data from the scientific publications and our findings are essential to achieving a correct diagnosis. On these bases, we suggest autoptic criteria to achieve a post-mortem diagnosis of AIPHI.
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