Evidence map›Paper›PMID 37046445›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Relationship of Vessel Density to Vessel Length Density in Patients with Treated Fabry Disease.

Maximilian Robert Justus Wiest, Mario Damiano Toro, Albina Nowak, Anahita Bajka, Katrin Fasler, Mayss Al-Sheikh, Timothy Hamann, Sandrine Anne Zweifel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Maximilian Robert Justus WiestDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-7561-1805
Mario Damiano ToroDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-7152-2613
Albina NowakDepartment of Endocrinology and Clinical Nutrition, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Anahita BajkaDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Katrin FaslerDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Mayss Al-SheikhDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-3364-2232
Timothy HamannDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Sandrine Anne ZweifelDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-7431-1774
University of Zurich · CHMedical University of Lublin · PL

Funding

Novartis Pharma CH AG (unrestricted research grant)
6 · The paper itself

Abstract

backgroundFabry disease (FD) is a potentially lethal lysosomal disorder with systemic vascular changes. Previous studies demonstrated retinal vascular involvement using optical coherence tomography angiography (OCTA) in affected patients; Aim: To analyze and quantify the retinal vasculature measuring vessel density (VD), vessel length density (VLD), and the ratio of VD to VLD (VD/VLD) in superficial capillary plexuses (SCP) and deep capillary plexuses (DCP) using OCTA in patients with FD and to show whether they differ from healthy controls (HC); Patients and methods: Single-center, retrospective, consecutive cohort study of patients with genetically proven FD. Patients underwent an ophthalmological examination including OCTA. VD, VLD, foveal avascular zone (FAZ), and the VD/VLD were compared to an HC group using a linear mixed model; Results: A statistically significant difference in the VLD and VD/VLD of DCP was observed between the two groups (

Indexed as

Fabry diseaselysosomal storage disorderOCTA parametersoptical coherence tomography angiography (OCTA)vessel densityvessel length density

Identifiers

PMID37046445
PMCPMC10093750
OpenAlexW4360851408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.