Evidence map›Paper›PMID 37046217›Full record

ArticleThe journal of physiological sciences : JPS2023

Acute effects of empagliflozin on open-loop baroreflex function and urine glucose excretion in Goto-Kakizaki diabetic rats.

Toru Kawada, Hiromi Yamamoto, Aimi Yokoi, Akitsugu Nishiura, Midori Kakuuchi, Shohei Yokota, Hiroki Matsushita, Joe Alexander, Keita Saku

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan. torukawa@ncvc.go.jp.ORCID 0000-0002-4429-1802
Hiromi YamamotoDepartment of Cardiovascular Medicine, Kurashiki Central Hospital, Ohara HealthCare Foundation, Okayama, 710-8602, Japan.
Aimi YokoiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Akitsugu NishiuraDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Midori KakuuchiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Shohei YokotaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Hiroki MatsushitaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Joe AlexanderMedical and Health Informatics, NTT Research, Inc., Sunnyvale, CA, 94085, USA.
Keita SakuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
National Cerebral and Cardiovascular Center · JPKurashiki Central Hospital · JPMolecular Medicine Research Institute · US

Funding

Intramural Research Fund for Cardiovascular Diseases of National Cerebral and Cardiovascular Center 21-2-7Intramural Research Fund for Cardiovascular Diseases of National Cerebral and Cardiovascular Center 21-2-9Japan Agency for Medical Research and Development 22ama121050j0001Japan Society for the Promotion of Science 20K20622Japan Society for the Promotion of Science 22K08222research program of the Ministry of Internal Affairs and Communications SCOPE: JP225006004
6 · The paper itself

Abstract

Although suppression of sympathetic activity is suggested as one of the underlying mechanisms for the cardioprotective effects afforded by sodium-glucose cotransporter 2 (SGLT2) inhibitors, whether the modulation of glucose handling acutely affects sympathetic regulation of arterial pressure remains to be elucidated. In Goto-Kakizaki diabetic rats, we estimated the open-loop static characteristics of the carotid sinus baroreflex together with urine glucose excretion using repeated 11-min step input sequences. After the completion of the 2nd sequence, an SGLT2 inhibitor empagliflozin (10 mg kg

Indexed as

BaroreflexDiabetes Mellitus, ExperimentalAnimalsArterial PressureBenzhydryl CompoundsBlood PressureGlucoseGlucosidesRatsBenzhydryl CompoundsempagliflozinGlucoseGlucosidesArterial pressureEquilibrium diagramSodium–glucose cotransporter 2Sympathetic nerve activityUrine flow

Identifiers

PMID37046217
PMCPMC10715593
OpenAlexW4365138463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.