ArticleNature2023
The evolution of lung cancer and impact of subclonal selection in TRACERx.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 188 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 1 pooled it
74.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
188 citing papers in PubMed, 1 synthesis or guideline pooled it, 286 citations in OpenAlex.
- Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis.Molecular diagnosis & therapy · 2026Pooled it
- Trial
- A Living Multi-Omics PDX Biobank of High-Risk Sarcomas Reveals ecDNA-Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review).Oncology reports · 2026Review
- Integrating clinical outcomes with molecular simulations to guide the selection of non-classical EGFR-TKIs: A comprehensive analysis and development of treatment strategies.Experimental and therapeutic medicine · 2026Article
- ClonalLife science alliance · 2026Article
- Multifocal ground-glass opacities in lung cancer: a narrative review of genomic evolution, immune ecology, and biology-informed clinical management.Journal of thoracic disease · 2026Review
- Phylogenetic and phylodynamic approaches to understanding the evolution of non-small cell lung cancer using single-cell sequencing.Oncogene · 2026Article
- Review
- Review
- Precision nanomedicine for pulmonary diseases: from molecular targeting to clinical translation.Signal transduction and targeted therapy · 2026Review
- mRNA-based therapeutics in lung Cancer: Mechanisms, applications, and translational challenges.Journal, genetic engineering & biotechnology · 2026Review
- Deconvolution of evolutionary architecture unmasks a high-risk, subclonal-rich subtype in treatment-naive small cell lung cancer.Journal of thoracic disease · 2026Article
- Longitudinal In Vivo Imaging at Single-Lesion Resolution Identifies Allele-Associated Response and Resistance Dynamics in EGFR-Mutant Lung Cancer.International journal of molecular sciences · 2026Article
- Agent-Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatiotemporal heterogeneity in non-small cell lung cancer: A paradigm shift from characterization to dynamic management (Review).Oncology letters · 2026Review
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples.Nature genetics · 2026Article
- Recent advances in engineered nanozymes for precision lung cancer therapy.Materials today. Bio · 2026Review
- Functionalized Coacervates for Cancer Therapy: Advances and Prospects in Phase-Separation-Based Intelligent Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
128 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
81 authors at 20 institutions in 9 countries.
Alexander M Frankell *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-0341-7878
Michelle Dietzen *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6853-7563
Maise Al Bakir *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-0846-8332
Emilia L Lim *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Takahiro Karasaki *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-6863-2360
Sophia Ward *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6777-5279
Selvaraju Veeriah *Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Emma Colliver *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1497-0740
Ariana Huebner *Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-8009-4999
Abigail Bunkum *Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-7753-9421
Mark S HillCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-0718-8934
Kristiana GrigoriadisCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-8435-0176
David A MooreCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6296-1312
James R M BlackCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Wing Kin LiuCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Kerstin TholCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Oriol PichCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1956-1882
Thomas B K WatkinsCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cristina Naceur-LombardelliCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Daniel E CookCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-3347-562X
Roberto SalgadoDepartment of Pathology, ZAS Hospitals, Antwerp, Belgium.
Gareth A WilsonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Chris BaileyCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Mihaela AngelovaCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-0495-9695
Robert BenthamCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Carlos Martínez-RuizCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-4817-0565
Christopher AbboshCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-8983-1382
Andrew G NicholsonDepartment of Histopathology, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
John Le QuesneCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-3552-7446
Dhruva BiswasCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-9141-5188
Rachel RosenthalCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Clare PuttickCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Sonya HesseyCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0001-9856-424X
Claudia LeeCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1715-2265
Paulina PrymasCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Antonia TonchevaCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Jon SmithScientific Computing, The Francis Crick Institute, London, UK.
Wei XingScientific Computing, The Francis Crick Institute, London, UK.
Jerome NicodAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2459-3480
Gillian PriceDepartment of Medical Oncology, Aberdeen Royal Infirmary NHS Grampian, Aberdeen, UK.
Keith M KerrUniversity of Aberdeen, Aberdeen, UK.
Babu NaiduBirmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Gary MiddletonUniversity Hospital Birmingham NHS Foundation Trust, Birmingham, UK.ORCID http://orcid.org/0000-0001-5695-3474
Kevin G BlythCancer Research UK Beatson Institute, Glasgow, UK.
Dean A FennellUniversity of Leicester, Leicester, UK.
Martin D ForsterCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Siow Ming LeeCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Mary FalzonDepartment of Cellular Pathology, University College London Hospitals, London, UK.
Madeleine HewishRoyal Surrey Hospital, Royal Surrey Hospitals NHS Foundation Trust, Guilford, UK.
Michael J ShackclothLiverpool Heart and Chest Hospital, Liverpool, UK.
Eric LimAcademic Division of Thoracic Surgery, Imperial College London, London, UK.
Sarah BenafifDepartment of Oncology, University College London Hospitals, London, UK.
Peter RussellPrincess Alexandra Hospital, The Princess Alexandra Hospital NHS Trust, Harlow, UK.
Ekaterini BoletiRoyal Free Hospital, Royal Free London NHS Foundation Trust, London, UK.
Matthew G KrebsDivision of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, UK.
Jason F LesterSingleton Hospital, Swansea Bay University Health Board, Swansea, UK.
Dionysis Papadatos-PastosDepartment of Oncology, University College London Hospitals, London, UK.
Tanya AhmadDepartment of Oncology, University College London Hospitals, London, UK.
Ricky M ThakrarDepartment of Thoracic Medicine, University College London Hospitals, London, UK.
David LawrenceDepartment of Thoracic Surgery, University College London Hospital NHS Trust, London, UK.
Neal NavaniDepartment of Thoracic Medicine, University College London Hospitals, London, UK.
Sam M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Caroline DiveCancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester, Manchester, UK.
Fiona H BlackhallDivision of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, UK.
Yvonne SummersDivision of Cancer Sciences, The University of Manchester and The Christie NHS Foundation Trust, Manchester, UK.
Judith CaveDepartment of Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Teresa MarafiotiDepartment of Cellular Pathology, University College London Hospitals, London, UK.
Javier HerreroBill Lyons Informatics Centre, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0001-7313-717X
Sergio A QuezadaCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-9763-1700
Karl S PeggsDepartment of Haematology, University College London Hospitals, London, UK.
Roland F SchwarzInstitute for Computational Cancer Biology, Center for Integrated Oncology (CIO), Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Peter Van LooDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0292-1949
Daniël M MiedemaLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Nicolai J BirkbakCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1613-9587
Crispin T HileyCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Allan HackshawCancer Research UK and UCL Cancer Trials Centre, London, UK.ORCID http://orcid.org/0000-0002-5570-5070
Simone ZaccariaCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-5265-7392
TRACERx Consortium
Mariam Jamal-HanjaniCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. m.jamal-hanjani@ucl.ac.uk.ORCID http://orcid.org/0000-0003-1212-1259
Nicholas McGranahanCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.ORCID http://orcid.org/0000-0001-9537-4045
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.ORCID http://orcid.org/0000-0002-4299-3018
The Francis Crick Institute · GBCancer Research UK · GBLondon Cancer · GBRoyal London Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBManchester University NHS Foundation Trust · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity Hospitals of Leicester NHS Trust · GBUniversity of Leicester · GBUniversity Hospital Southampton NHS Foundation Trust · GBGolden Jubilee National Hospital · GBUniversity College Hospital · GBUniversity College London · GBAberdeen Royal Infirmary · GBInstitute of Cancer Research · GBUniversity of Manchester · GBAarhus University · DKCancer Research UK Manchester CentreNHS Greater Glasgow and Clyde · GBThe Christie NHS Foundation Trust · GB
Funding
Cancer Research UK 17786Cancer Research UK 21999Cancer Research UK 24956Cancer Research UK 25354Cancer Research UK 29569Cancer Research UK 30025Cancer Research UK CTRNBC-2022/100001Cancer Research UK CTUQQR-DEC22/100009Medical Research Council MR/T02481X/1Medical Research Council MR/V033077/1Medical Research Council MR/W025051/1Wellcome Trust CC2008Wellcome Trust CC2041
Abstract
Lung cancer is the leading cause of cancer-associated mortality worldwide
Indexed as
Carcinoma, Non-Small-Cell LungLung NeoplasmsAdenocarcinoma of LungAnaplastic Lymphoma KinaseDNA Copy Number VariationsErbB ReceptorsHumansMutagenesisMutationNeoplasm Recurrence, LocalPhylogenyProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metProto-Oncogene Proteins c-retSmokingALK protein, humanAnaplastic Lymphoma KinaseEGFR protein, humanErbB ReceptorsMET protein, humanProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metProto-Oncogene Proteins c-retRET protein, humanROS1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.