Evidence map›Paper›PMID 37046092›Full record

ArticleNature2023

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Joselyn S Soto, Yasaman Jami-Alahmadi, Jakelyn Chacon, Stefanie L Moye, Blanca Diaz-Castro, James A Wohlschlegel, Baljit S Khakh

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  12. Article
  13. Article
  14. Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  15. Review
  16. Review
  17. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  18. Article
  19. Article
  20. Label-Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Joselyn S SotoDepartment of Physiology, University of California, Los Angeles, CA, USA.
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8289-2222
Jakelyn ChaconDepartment of Physiology, University of California, Los Angeles, CA, USA.
Stefanie L MoyeDepartment of Physiology, University of California, Los Angeles, CA, USA.
Blanca Diaz-CastroDepartment of Physiology, University of California, Los Angeles, CA, USA.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Baljit S KhakhDepartment of Physiology, University of California, Los Angeles, CA, USA. bkhakh@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-0939-1218
University of California, Los Angeles · US

Funding

Fundamental astrocyte biology in intact neural circuitsR35NS111583 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Baljit Khakh · 2019 to 2026
$7.9M
New tools to target, identify and characterize astrocytes in the adult nervous systemR01DA047444 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRADINARU, VIVIANA, KHAKH, BALJIT · 2018 to 2020
$3.3M
NIDA NIH HHS R01 DA047444NINDS NIH HHS R35 NS111583
6 · The paper itself

Abstract

Astrocytes and neurons extensively interact in the brain. Identifying astrocyte and neuron proteomes is essential for elucidating the protein networks that dictate their respective contributions to physiology and disease. Here we used cell-specific and subcompartment-specific proximity-dependent biotinylation

Indexed as

AstrocytesNeuronsObsessive-Compulsive DisorderProteomeActin CytoskeletonAnimalsBiotinylationCell MembraneCytosolHomeostasisMiceNerve Tissue ProteinsPhenotypeSignal TransductionNerve Tissue ProteinsProteomeSapap3 protein, mouse

Identifiers

PMID37046092
PMCPMC10132990
OpenAlexW4365143658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.