ArticleNature2023
Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
43.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.
- Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA.Frontiers in genetics · 2024Pooled it
- Article
- Extrachromosomal Circular DNA May Contribute to Histopathologic Characteristics in Esophageal Combined Basaloid Squamous Cell Carcinoma.Annals of surgical oncology · 2026Article
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints.bioRxiv : the preprint server for biology · 2026Article
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- scAmp enables focal gene amplification analysis from single-cell data.Nature communications · 2026Article
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Beyond chromosomes: exploring the diverse functions of extrachromosomal circular DNA.Journal of advanced research · 2026Review
- A bibliometric analysis of extrachromosomal DNA in cancer over six decades.Discover oncology · 2026Article
- Preservation and clonal behavior of extrachromosomal DNA in patient-derived xenograft models of childhood cancers.Genome medicine · 2026Article
- High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities.Nature communications · 2026Article
- The potential clinical implications of extrachromosomal circular DNA as a biomarker.Genes & diseases · 2026Review
- Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma.Nature medicine · 2026Article
- Targeting extrachromosomal DNA in human cancers.Nature reviews. Drug discovery · 2026Review
- The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS letters · 2026Review
- Review
- Fast and accurate resolution of ecDNA sequence using Cycle-Extractor.bioRxiv : the preprint server for biology · 2026Article
- Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026Review
- Convergent evolution of complex structural variants drives therapy resistance in metastatic prostate cancer.Genome biology · 2026Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
20 authors at 11 institutions in 3 countries.
Jens LuebeckDepartment of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4391-979X
Alvin Wei Tian NgEarly Cancer Institute, Hutchison Research Centre, University of Cambridge, Cambridge, UK.
Patricia C GalipeauDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7961-7430
Xiaohong LiClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4438-2664
Carissa A SanchezDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Annalise C Katz-SummercornEarly Cancer Institute, Hutchison Research Centre, University of Cambridge, Cambridge, UK.
Hoon KimDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Republic of Korea.
Sriganesh JammulaEarly Cancer Institute, Hutchison Research Centre, University of Cambridge, Cambridge, UK.
Yudou HeMoores Cancer Center, UC San Diego Health, La Jolla, CA, USA.
Scott M LippmanMoores Cancer Center, UC San Diego Health, La Jolla, CA, USA.
Roel G W VerhaakThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0003-2773-0436
Carlo C MaleyBiodesign Institute, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0002-0745-7076
Ludmil B AlexandrovMoores Cancer Center, UC San Diego Health, La Jolla, CA, USA.
Brian J ReidDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Rebecca C FitzgeraldEarly Cancer Institute, Hutchison Research Centre, University of Cambridge, Cambridge, UK. rcf29@mrc-cu.cam.ac.uk.
Thomas G PaulsonClinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. tpaulson@fredhutch.org.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu.ORCID http://orcid.org/0000-0002-9459-4393
Sihan WuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Sihan.Wu@UTSouthwestern.edu.ORCID http://orcid.org/0000-0001-8329-7492
Vineet BafnaDepartment of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA. vbafna@ucsd.edu.ORCID http://orcid.org/0000-0002-5810-6241
Paul S MischelDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. pmischel@stanford.edu.ORCID http://orcid.org/0000-0002-4560-2211
Fred Hutch Cancer Center · USUniversity of Cambridge · GBUC San Diego Health System · USUniversity of California San Diego · USArizona State University · USChildren's Medical Center · USHoward Hughes Medical Institute · USJackson Laboratory · USStanford Health Care · USSungkyunkwan University · KRUniversity of Washington · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MVIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MShared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MPHYLOGENIES of Barrett's Esophagus LineagesP01CA091955 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY · 2002 to 2019
$35.9MUniversity of Arizona Cancer Prevention Clinical Trials Network (UA CP-CTNet)UG1CA242596 · NCI · UNIVERSITY OF ARIZONA · PI Julie E Bauman, Patricia Ann Thompson · 2019 to 2026
$11.5MThe Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO, SHIBATA, DARRYL K · 2018 to 2022
$8.6MeDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7MModeling Neoplastic Progression in Barrett's Esophagus - Renewal -2R01CA140657 · NCI · WISTAR INSTITUTE · PI Carlo Maley · 2009 to 2026
$5.0MTargeting Signaling Vulnerabilities for Oral Cancer PreventionR01DE026644 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jorge Silvio Gutkind, SCOTT M LIPPMAN · 2017 to 2026
$4.7MSoftware and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNAU24CA264379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, MESIROV, JILL P. · 2021 to 2025
$3.5MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MIntegrated ligand and target discovery by chemical proteomics for glioblastoma treatment.R01CA238249 · NCI · STANFORD UNIVERSITY · PI CRAVATT, BENJAMIN F, MISCHEL, PAUL S · 2021 to 2025
$3.3MCancer Research UK CGCATF-2021/100012Medical Research Council MR/W014122/1NCI NIH HHS HHSN261201200031CNCI NIH HHS HHSN261201200031INCI NIH HHS OT2 CA278635NCI NIH HHS OT2 CA278649NCI NIH HHS OT2 CA278683NCI NIH HHS OT2 CA278688NCI NIH HHS P01 CA091955NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA140657NCI NIH HHS R01 CA237208NCI NIH HHS R01 CA238249NCI NIH HHS R01 CA238379NCI NIH HHS R21 CA256575NCI NIH HHS R33 CA236681NCI NIH HHS U24 CA264379NCI NIH HHS U54 CA217376NCI NIH HHS UG1 CA242596NIDCR NIH HHS R01 DE026644NIEHS NIH HHS R01 ES030993NIEHS NIH HHS R01 ES032547NIGMS NIH HHS R01 GM114362NINDS NIH HHS R21 NS114873
Abstract
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer
Indexed as
AdenocarcinomaBarrett EsophagusCarcinogenesisDisease ProgressionDNAEarly Detection of CancerEsophageal NeoplasmsBiopsyCase-Control StudiesCohort StudiesDNA Copy Number VariationsGene AmplificationHumansImmunomodulationOncogenesWhole Genome SequencingDNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.