ArticleNature2023
Ageing-associated changes in transcriptional elongation influence longevity.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
27.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
132 citing papers in PubMed, 182 citations in OpenAlex.
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- Proteostasis of organelles in aging and disease.The FEBS journal · 2026Review
- Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program.Nature aging · 2026Article
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- Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging.Science China. Life sciences · 2026Article
- RNA imbalance as a hallmark of cellular ageing.Nature cell biology · 2026Review
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- HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging.Research square · 2026Article
- An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation.npj aging · 2026Article
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.The EMBO journal · 2026Article
- Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed.Science advances · 2026Article
- Host insulin hijacking by a nematode receptor mediates developmental plasticity and sex ratio shifts.Nature communications · 2026Article
- Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing.bioRxiv : the preprint server for biology · 2026Article
- Native entanglement misfolding contributes to age-associated structural changebioRxiv : the preprint server for biology · 2026Article
- Unraveling the complexity of skin's biological aging utilizing epigenetic clocks.Clinical epigenetics · 2026Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 3 institutions in 2 countries.
Cédric Debès *Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Antonios Papadakis *Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Sebastian Grönke *Max Planck Institute for Biology of Ageing, Cologne, Germany.ORCID http://orcid.org/0000-0002-1539-5346
Özlem Karalay *Max Planck Institute for Biology of Ageing, Cologne, Germany.
Luke S TainMax Planck Institute for Biology of Ageing, Cologne, Germany.
Athanasia MiziInstitute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Shuhei NakamuraMax Planck Institute for Biology of Ageing, Cologne, Germany.
Oliver HahnCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Carina WeigeltMax Planck Institute for Biology of Ageing, Cologne, Germany.
Natasa JosipovicInstitute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Anne ZirkelCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Isabell BrusiusCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-2568-1351
Konstantinos SofiadisInstitute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Mantha LamprousiInstitute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.
Yu-Xuan LuMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID http://orcid.org/0000-0001-6751-5250
Wenming HuangMax Planck Institute for Biology of Ageing, Cologne, Germany.
Reza EsmaillieCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Torsten KubackiDepartment II of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-7723-9659
Martin R SpäthCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-1624-0055
Bernhard SchermerCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-5194-9000
Thomas BenzingCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-0512-1066
Roman-Ulrich MüllerCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6910-0745
Adam AntebiCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. aantebi@age.mpg.de.ORCID http://orcid.org/0000-0002-7241-3029
Linda PartridgeCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. partridge@age.mpg.de.ORCID http://orcid.org/0000-0001-9615-0094
Argyris PapantonisInstitute of Pathology, University Medical Centre Göttingen, Göttingen, Germany. argyris.papantonis@med.uni-goettingen.de.ORCID http://orcid.org/0000-0001-7551-1073
Andreas BeyerCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. andreas.beyer@uni-koeln.de.ORCID http://orcid.org/0000-0002-3891-2123
University of Cologne · DEMax Planck Institute for Biology of Ageing · DETH Köln - University of Applied Sciences · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing
Indexed as
AgingLongevityTranscription Elongation, GeneticAnimalsCaenorhabditis elegansCaloric RestrictionCell DivisionDrosophila melanogasterHistonesHumansInsulinMiceNucleosomesRatsRNA, CircularRNA Polymerase IIHistonesInsulinNucleosomesRNA, CircularRNA Polymerase IISomatomedins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.