ArticleNature2023
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
28.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Effects of donor-engrafted clonal hematopoiesis in allogeneic and autologous stem cell transplantation: a systematic review and meta-analysis.Bone marrow transplantation · 2024Pooled it
- Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.Nature communications · 2024Pooled it
- Clonal hematopoiesis is associated with protection from Alzheimer's disease.Nature medicine · 2023Pooled it
- Genetic mechanisms of mitotic error in 840,853 blood genomes.medRxiv : the preprint server for health sciences · 2026Article
- Review
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Article
- Article
- Statin Use and Genetically Predicted HMG-CoA Reductase Inhibition in Relation to Clonal Hematopoiesis.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Population-Based Identification of Clonal Hematopoiesis Using Peripheral Blood Whole-Genome Sequencing in Japan.Cancer science · 2026Article
- Age distinguishes selection from causation in cancer genomes.Nature genetics · 2026Article
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- Association of infection frequency and incident clonal hematopoiesis of indeterminant potential.Experimental hematology · 2026Article
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
- Review
- Inflammageing and clonal haematopoiesis interplay and their impact on human disease.Nature reviews. Molecular cell biology · 2026Review
- Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X-Inactivation Features.Aging cell · 2026Article
- Novel and emerging therapeutic strategies for clonal hematopoiesis.Haematologica · 2026Review
- Clonal hematopoiesis and its progression to myeloid neoplasms: insights into risk, biology, and therapeutic strategies.Haematologica · 2026Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
112 authors at 20 institutions in 9 countries.
Joshua S Weinstock *Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7013-1899
Jayakrishnan Gopakumar *Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3895-8188
Bala Bharathi BurugulaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1114-6964
Md Mesbah UddinProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1846-0411
Nikolaus JahnDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Julia A BelkDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Hind BouzidDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Bence DanielDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2410-8767
Zhuang MiaoDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Nghi LyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Taralynn M MackDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1043-2950
Sofia E LunaDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Katherine P ProthroDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Shaneice R MitchellDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9297-781X
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6569-2501
Jai G BroomeDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Moritz F SinnerDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.
Aenne S von FalkenhausenDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.
Stefan KääbDepartment of Medicine I, University Hospital, LMU Munich, Munich, Germany.
Alan R ShuldinerDepartment of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.
Jeffrey R O'ConnellDepartment of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.
Joshua P LewisDepartment of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4107-6066
Eric BoerwinkleHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Kathleen C BarnesDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-3030-4705
Nathalie ChamiThe Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.
Eimear E KennyInstitute for Genomic Health, New York, NY, USA.
Ruth J F LoosThe Charles Bronfman Institute of Personalized Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Myriam FornageUniversity of Texas Health at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Lifang HouDepartment of Preventive Medicine, Northeastern University, Chicago, IL, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northeastern University, Chicago, IL, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6585-1610
Brian E CadeProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1424-0673
Bruce M PsatyUniversity of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Jennifer A BrodyUniversity of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Edwin K SilvermanBrigham and Women's Hospital, Boston, MA, USA.
Jeong H YunChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Dandi QiaoBrigham and Women's Hospital, Boston, MA, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael H ChoBrigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4907-1657
Dawn L DeMeoBrigham and Women's Hospital, Boston, MA, USA.
Ramachandran S VasanNational Heart Lung and Blood Institute's, Boston University's Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-7357-5970
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Lewis C BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9717-8459
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2581-070X
Pim Van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7100-512X
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3483-353X
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2749-1279
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Marguerite R IrvinUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Hemant TiwariDepartment of Biostatistics, University of Alabama, Birmingham, AL, USA.
Michael J CutlerIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-9498-7472
Stacey KnightIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0092-7327
J Brent MuhlesteinIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA.
Adolfo CorreaDepartment of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-9501-600X
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yan GaoDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Mariza de AndradeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Stephen S RichDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Russell P TracyDepartment of Pathology and Laboratory Medicine and Biochemistry, Larner College of Medicine at the University of Vermont, Colchester, VT, USA.
Barbara A KonkleDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Jill M JohnsenDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Marsha M WheelerGenome Science, University of Washington, Seattle, WA, USA.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Olle MelanderDepartment of Internal Medicine, Clinical Sciences, Lund University and Skane University Hospital, Malmo, Sweden.
Peter M NilssonDepartment of Internal Medicine, Clinical Sciences, Lund University and Skane University Hospital, Malmo, Sweden.ORCID http://orcid.org/0000-0002-5652-8459
Brian S CusterVitalant Research Institute, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6251-366X
Ravindranath DuggiralaDepartment of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Joanne E CurranDepartment of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID http://orcid.org/0000-0002-6898-155X
John BlangeroDepartment of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID http://orcid.org/0000-0001-6250-5723
Stephen McGarveyDepartment of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA.ORCID http://orcid.org/0000-0003-1233-6970
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Shujie XiaoCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Mao YangCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.
Yii-Der Ida ChenDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Gregory M MarcusDivision of Cardiology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5197-7696
John P KaneDepartment of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Clive R PullingerCardiovascular Research Institute, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0003-3213-1374
M Benjamin ShoemakerDivision of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Dawood DarbarDivision of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4103-5977
Dan M RodenDepartments of Medicine, Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Christine AlbertDepartment of Cardiology, Cedars-Sinai, Los Angeles, CA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7986-8560
Ying ZhouDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
JoAnn E MansonBrigham and Women's Hospital, Boston, MA, USA.
Pinkal DesaiDivision of Hematology and Oncology, Weill Cornell Medicine, New York, NY, USA.
Andrew D JohnsonNational Heart, Lung and Blood Institute, Population Sciences Branch, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-6369-5178
Rasika A MathiasDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2282-9042
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Thomas W BlackwellCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Goncalo R AbecasisCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Albert V SmithCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1942-5845
Hyun M KangCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5167-537X
Pradeep NatarajanProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Jacob O KitzmanDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6145-882X
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4843-3641
Alexander P ReinerBroad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1427-4470
Alexander G BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA. alexander.bick@vumc.org.ORCID http://orcid.org/0000-0001-5824-9595
Siddhartha JaiswalDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sjaiswal@stanford.edu.ORCID http://orcid.org/0000-0002-9597-0477
University of Washington · USBrigham and Women's Hospital · USUniversity of Maryland, Baltimore · USUniversity of Michigan · USBaylor College of Medicine · USJohns Hopkins University · USUniversity of Colorado Denver · USBroad Institute · USStanford University · USNational Institutes of Health · USNew York Genome Center · USLund University · SEThe University of Texas Rio Grande Valley · USWashington University in St. Louis · USFred Hutch Cancer Center · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USAtrium Health Wake Forest Baptist · USEmory University · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2016 to 2020
$12.6MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MStem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCenter for Hemoglobin Research in Minorities (CHaRM)P50HL118006 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2013 to 2017
$7.0MSUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0MSickle Cell Disease and Sickle Cell Trait Protection Against HIV-1-infection in Africans and African AmericansR01HL125005 · NHLBI · HOWARD UNIVERSITY · PI MARINA A JEREBTSOVA, SERGEI NEKHAI · 2014 to 2026
$6.7MT32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MNHLBI NIH HHS DP2 HL157540NHLBI NIH HHS HHSN268201000001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL146972NHLBI NIH HHS P01 HL132825NHLBI NIH HHS P50 HL118006NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL125005NHLBI NIH HHS R01 HL143818NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL153805NHLBI NIH HHS T32 HL098049NHLBI NIH HHS U01 HL120393NIAID NIH HHS R01 AI132476NIA NIH HHS K01 AG059898NICHD NIH HHS P50 HD105352NIDDK NIH HHS P30 DK040561NIDDK NIH HHS U54 DK106829NIH HHS DP5 OD029586NIH HHS S10 OD026880NIH HHS S10 OD030463
Abstract
Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis
Indexed as
Clonal HematopoiesisHematopoietic Stem CellsAllelesAnimalsDioxygenasesDNA-Binding ProteinsDNA Methyltransferase 3AGenome-Wide Association StudyHematopoiesisHumansMiceMutationPromoter Regions, GeneticProto-Oncogene ProteinsRepressor ProteinsASXL1 protein, humanDioxygenasesDNA-Binding ProteinsDNA Methyltransferase 3ADNMT3A protein, humanProto-Oncogene ProteinsRepressor ProteinsTCL1A protein, humanTcl1 protein, mouseTET2 protein, human
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.