ArticleParasitology research2023
Molecular evidence for a new lineage within the Acanthamoeba T4 genotype.
Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Molecular Typing ofMicroorganisms · 2025Article
- Comparative genomic analysis ofmSphere · 2024Article
- Learning from the rDNA Operon: A Reanalysis of theMicroorganisms · 2024Article
- Article
- Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations.Translational vision science & technology · 2024Article
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Authors and funding
2 authors.
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Abstract
Acanthamoeba is a widespread free-living amoeba capable of causing serious infections in humans and other animals, such as amoebic keratitis, disseminated infections, and fatal encephalitis. Strain identification is usually based on 18S rDNA sequencing, which allows the distinction of over twenty genotypes. Most sequences from environmental and clinical samples belong to the T4 genotype, which can be divided into seven subtypes, T4A to T4G, and by a nearly similar grouping of mitochondrial sequences into T4a to T4j subtypes. The co-clustering of nuclear and mitochondrial groups can be very useful for a better identification of lineages within the very rich T4 genotype. In this study, we provided molecular phylogenetic evidence for the delineation of a new nuclear subtype, hereafter labelled T4H, and its co-clustering with the mitochondrial T4j subtype. At least three cases of amoebic keratitis are due to strains belonging to this new group, present mainly in fresh water and detected in various countries (France, Iran, India and China).
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