ReviewNature protocols2023
Graphene-molecule-graphene single-molecule junctions to detect electronic reactions at the molecular scale.
Review in Nature protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Metal-Enhanced Charge Transport and its Mechanism in Atomically Precise Ruthenium Single-Molecule Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanically Induced Switching Between Orbital- and Fano-Resonance Rectification in a Dual-Anchored Molecular Junction.Angewandte Chemie (International ed. in English) · 2026Article
- Origin of Single-Molecule Reaction Chirality.Research (Washington, D.C.) · 2026Article
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Nanosecond-scale single-molecule reaction dynamics for scalable synthesis on a chip.National science review · 2025Article
- Graphene-Based Organic Semiconductor Film for Highly Selective Photocatalytic CONanomaterials (Basel, Switzerland) · 2025Article
- Quasi-Continuous Efficient Regulation of Single-Molecule Electronic Distribution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emergent complexity of quantum rotation tunneling.Science advances · 2025Article
- Full on-device manipulation of olefin metathesis for precise manufacturing.Nature nanotechnology · 2025Article
- Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance.Biosensors · 2025Review
- Unveiling the Mechanism of Deprotonation and Proton Transfer of DNA Polymerase Catalysis via Single-Molecule Conductance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gated off-site radical injection: Bidirectional conductance modulation in single-molecule junctions.Science advances · 2024Article
- Reply to: Questioning claims of monitoring the Michael addition reaction at the single-molecule level.Nature chemistry · 2024Article
- Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges.Precision chemistry · 2024Review
- Electrical monitoring of single-event protonation dynamics at the solid-liquid interface and its regulation by external mechanical forces.Nature communications · 2024Article
- Dynamically blocking leakage current in molecular tunneling junctions.Chemical science · 2024Article
- Toward Practical Single-Molecule/Atom Switches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The ability to measure the behavior of a single molecule during a reaction implies the detection of inherent dynamic and static disordered states, which may not be represented when measuring ensemble averages. Here, we describe the building of devices with graphene-molecule-graphene single-molecule junctions integrated into an electrical circuit. These devices are simple to build and are stable, showing tolerance to mechanical changes, solution environment and voltage stimulation. The design of a conductive channel based on a single molecule enables single-molecule detection and is sensitive to variations in physical properties and chemical structures of the detected molecules. The on-chip setup of single-molecule junctions further offers complementary metal-oxide-semiconductor (CMOS) compatibility, enabling logic functions in circuit elements, as well as deciphering of reaction intermediates. We detail the experimental procedure to prepare graphene transistor arrays as a basis for single-molecule junctions and the preparation of nanogapped carboxyl-terminal graphene electrodes by using electron-beam lithography and oxygen plasma etching. We describe the basic design of a molecular bridge with desired functions and terminals to form covalent bonds with electrode arrays, via a chemical reaction, to construct stably integrated single-molecule devices with a yield of 30-50% per chip. The immobilization of the single molecules is then characterized by using inelastic electron tunneling spectra, single-molecule imaging and fluorescent spectra. The whole protocol can be implemented within 2 weeks and requires users trained in using ultra-clean laboratory facilities and the aforementioned instrumentation.
Indexed as
Identifiers
37045993What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.