Trial reportNature communications2023
A case study of percutaneous epidural stimulation to enable motor control in two men after spinal cord injury.
Trial report in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transspinal Versus Epidural Stimulation for Exoskeletal Assisted Walking After Spinal Cord Injury
Epidural Stimulation and Resistance Training for Overground Locomotion After Spinal Cord Injury
Who cites it
23 citing papers in PubMed, 26 citations in OpenAlex.
- Postural changes and motor evoked potentials following percutaneous spinal cord epidural stimulation in spinal cord injury.Spinal cord series and cases · 2026Trial
- Functional outcomes and participants' perspectives during short-term application of spinal stimulation in individuals with spinal cord injury.The journal of spinal cord medicine · 2025Trial
- Spinal cord stimulation: An emerging strategy for chronic pain relief after spinal cord injury.Neural regeneration research · 2026Article
- Partitioning of the nervous system following exoskeleton and epidural stimulation in spinal cord injury.Scientific reports · 2026Article
- Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury.Journal of neurophysiology · 2026Article
- Robotic-Assisted Rehabilitation and Spinal Neuromodulation After Spinal Cord Injury: From Mechanisms to Trial-Informed Practice.Journal of clinical medicine · 2026Review
- The Interplay Between Neuromodulation and Stem Cell Therapy for Sensory-Motor Neuroplasticity After Spinal Cord Injury: A Perspective View.Journal of clinical medicine · 2026Article
- Hybrid 12-Month Exoskeleton Training with Percutaneous Epidural Stimulation After Spinal Cord Injury.Life (Basel, Switzerland) · 2026Article
- Research progress on the effects of epidural electrical stimulation on lower extremity function in patients with spinal cord injury.Frontiers in medicine · 2026Review
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Consumer views of functional electrical stimulation and robotic exoskeleton in SCI rehabilitation: A mini review.Artificial organs · 2025Review
- Epidural Stimulation and Resistance Training (REST-SCI) for Overground Locomotion After Spinal Cord Injury: Randomized Clinical Trial Protocol.Journal of clinical medicine · 2025Article
- Deep Brain Stimulation and Brain-Spine Interface for Functional Restoration in Spinal Cord Injury.Biomedicines · 2025Review
- Spatiotemporal spinal cord stimulation with real-time triggering exoskeleton restores walking capability: a case report.Annals of clinical and translational neurology · 2025Article
- Time Course of Motor Improvement by Epidural Stimulation After Spinal Cord Injury: An Interim Analysis of a Phase II Trial.Journal of central nervous system disease · 2025Article
- MRI Spinal Cord Reconstruction Provides Insights into Mapping and Migration Following Percutaneous Epidural Stimulation Implantation in Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries.Bioengineering (Basel, Switzerland) · 2024Review
- Electrical Stimulation and Motor Function Rehabilitation in Spinal Cord Injury: A Systematic Review.Cureus · 2024Review
- Peak Slope Ratio of the Recruitment Curves Compared to Muscle Evoked Potentials to Optimize Standing Configurations with Percutaneous Epidural Stimulation after Spinal Cord Injury.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Two persons with chronic motor complete spinal cord injury (SCI) were implanted with percutaneous spinal cord epidural stimulation (SCES) leads to enable motor control below the injury level (NCT04782947). Through a period of temporary followed by permanent SCES implantation, spinal mapping was conducted primarily to optimize configurations enabling volitional control of movement and training of standing and stepping as a secondary outcome. In both participants, SCES enabled voluntary increased muscle activation and movement below the injury and decreased assistance during exoskeleton-assisted walking. After permanent implantation, both participants voluntarily modulated induced torques but not always in the intended directions. In one participant, percutaneous SCES enabled motor control below the injury one-day following temporary implantation as confirmed by electromyography. The same participant achieved independent standing with minimal upper extremity self-balance assistance, independent stepping in parallel bars and overground ambulation with a walker. SCES via percutaneous leads holds promise for enhancing rehabilitation and enabling motor functions for people with SCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.