Evidence map›Paper›PMID 37045811›Full record

ArticleNature communications2023

Embryonic keratin19

Beth Lucas, Andrea J White, Fabian Klein, Clara Veiga-Villauriz, Adam Handel, Andrea Bacon, Emilie J Cosway, Kieran D James, Sonia M Parnell, Izumi Ohigashi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Generation and repair of thymic epithelial cells.The Journal of experimental medicine · 2024
    Review
  9. Article
  10. Aire in Autoimmunity.Annual review of immunology · 2024
    Review
  11. Article
  12. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Beth LucasInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.ORCID 0000-0003-2947-5432
Andrea J WhiteInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Fabian KleinDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-6208-8592
Clara Veiga-VillaurizDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.
Adam HandelDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-8385-6346
Andrea BaconInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Emilie J CoswayInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Kieran D JamesInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Sonia M ParnellInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Izumi OhigashiInstitute for Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID 0000-0003-0017-6957
Yousuke TakahamaThymus Biology Section, Experimental Immunology Branch, NCI/NIH, Bethesda, USA.ORCID 0000-0002-4992-9174
William E JenkinsonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Georg A HollanderDepartment of Paediatrics and Institute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-8790-0874
Wei-Yu LuCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Graham AndersonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK. g.anderson@bham.ac.uk.ORCID 0000-0002-2917-4085
University of Birmingham · GBUniversity of Oxford · GBQueen's Medical Centre · GBTokushima University · JPUniversity of Basel · CH

Funding

Medical Research Council MR/T029765/1Medical Research Council MR/T030798/2Wellcome TrustWellcome Trust 105045/Z/14/ZWellcome Trust 211944/Z/18/Z
6 · The paper itself

Abstract

The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is clear, the production and maintenance of mTEC diversity remains poorly understood. Here, using ontogenetic and inducible fate-mapping approaches, we identify mTEC-restricted progenitors as a cytokeratin19

Indexed as

Immune ToleranceKeratin-19Thymus GlandAnimalsCell DifferentiationEpithelial CellsMiceMice, Inbred C57BLStem CellsKeratin-19

Identifiers

PMID37045811
PMCPMC10097809
OpenAlexW4365141860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.