Evidence map›Paper›PMID 37045646›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2023

Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1.

Eellan Sivanesan, Karla R Sanchez, Chi Zhang, Shao-Qiu He, Bengt Linderoth, Kimberly E Stephens, Srinivasa N Raja, Yun Guan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Eellan SivanesanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: esivane1@jh.edu.
Karla R SanchezDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Chi ZhangDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Shao-Qiu HeDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Bengt LinderothDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Kimberly E StephensDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Research Institute, Little Rock, AR, USA.
Srinivasa N RajaDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Neurological Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USArkansas Children's Hospital · USKarolinska Institutet · SE

Funding

Interdisciplinary Training in Biobehavioral Pain ResearchT32NS070201 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG, SMITH, MICHAEL T · 2010 to 2024
$3.6M
Birth Tissue Products for Non-opioid Treatment of Post-surgical PainR01NS117761 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2020 to 2024
$2.6M
Mechanistic Study of Pain Inhibition by Activation of Non-nociceptive Afferent FibersR01NS110598 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2019 to 2024
$2.4M
Spinal cord stimulation for the attenuation of chemotherapy-induced peripheral neuropathy and enhanced chemotherapeutic efficacyK08CA255428 · NCI · JOHNS HOPKINS UNIVERSITY · PI SIVANESAN, EELLAN · 2021 to 2025
$1.4M
NCI NIH HHS K08 CA255428NINDS NIH HHS R01 NS110598NINDS NIH HHS R01 NS117761NINDS NIH HHS T32 NS070201
6 · The paper itself

Abstract

introductionDespite increasing utilization of spinal cord stimulation (SCS), its effects on chemoefficacy, cancer progression, and chemotherapy-induced peripheral neuropathy (CIPN) pain remain unclear. Up to 30% of adults who are cancer survivors may suffer from CIPN, and there are currently no effective preventative treatments. MATERIALS AND

methodsThrough a combination of bioluminescent imaging, behavioral, biochemical, and immunohistochemical approaches, we investigated the role of SCS and paclitaxel (PTX) on tumor growth and PTX-induced peripheral neuropathy (PIPN) pain development in T-cell-deficient male rats (Crl:NIH-Foxn1

resultsWe show that preemptive SCS enhanced the antitumor efficacy of PTX and prevented PIPN pain. Without SCS, rats with and without tumors developed robust PIPN pain-related mechanical hypersensitivity, but only those with tumors developed cold hypersensitivity, suggesting T-cell dependence for different PIPN pain modalities. SCS increased soluble CX3CL1 and macrophages and decreased neuronal and nonneuronal insoluble CX3CL1 expression and inflammation in dorsal root ganglia.

conclusionCollectively, our findings suggest that preemptive SCS is a promising strategy to increase chemoefficacy and prevent PIPN pain via CX3CL1-macrophage modulation.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeuralgiaSpinal Cord StimulationAnimalsChemokine CX3CL1Ganglia, SpinalHumansMalePaclitaxelRatsRats, Sprague-DawleySpinal CordChemokine CX3CL1CX3CL1 protein, humanPaclitaxelChemotherapychronic painnon–small cell lung cancerperipheral neuropathiesspinal cord stimulation

Identifiers

PMID37045646
PMCPMC10330336
OpenAlexW4364367211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.