Evidence map›Paper›PMID 37045597›Full record

ArticleeNeuro2023

A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.

Makoto Ohmoto, Masafumi Jyotaki, Karen K Yee, Ichiro Matsumoto

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Makoto OhmotoMonell Chemical Senses Center, Philadelphia, PA 19104.
Masafumi JyotakiMonell Chemical Senses Center, Philadelphia, PA 19104.
Karen K YeeMonell Chemical Senses Center, Philadelphia, PA 19104.
Ichiro MatsumotoMonell Chemical Senses Center, Philadelphia, PA 19104 imatsumoto@monell.org.
Monell Chemical Senses Center · US

Funding

Molecular BiologyP30DC011735 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MOSINGER, BEDRICH · 2011 to 2015
$2.5M
Molecular Genetics of Fat TasteR01DC017503 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MATSUMOTO, ICHIRO · 2019 to 2023
$1.6M
Roles of Ascl1 for generation and differentiation of taste cellsR01DC015491 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MATSUMOTO, ICHIRO · 2016 to 2020
$1.6M
Leica STELLARIS 5 Confocal MicroscopeS10OD030354 · OD · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2021 to 2021
$399k
NIDCD NIH HHS P30 DC011735NIDCD NIH HHS R01 DC015491NIDCD NIH HHS R01 DC017503NIH HHS S10 OD030354
6 · The paper itself

Abstract

Taste cells are maintained by continuous turnover throughout a lifetime, yet the mechanisms of taste cell differentiation, and how taste sensations remain constant despite this continuous turnover, remain poorly understood. Here, we report that a transcription factor Etv1 (also known as Er81) is involved in the differentiation of taste cells responsible for the preference for sweet, umami, and salty tastes. Molecular analyses revealed that

Indexed as

TasteTaste BudsAmilorideAnimalsCell DifferentiationDNA-Binding ProteinsMiceSodiumTranscription FactorsAmilorideDNA-Binding ProteinsEtv1 protein, mouseSodiumTranscription FactorsEtv1saltysweettaste cellumami

Identifiers

PMID37045597
PMCPMC10131560
OpenAlexW4365140011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.