Evidence map›Paper›PMID 37045477›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Involvement of specific striatal subregion contributes to executive deficits in Alzheimer disease.

Li Liu, Shaozhen Yan, Min Chu, Binbin Nie, Kexin Xie, Yue Cui, Deming Jiang, Zhongyun Chen, Haitian Nan, Pedro Rosa-Neto and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Li Liu *From the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Shaozhen Yan *From the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Min Chu *From the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Binbin NieFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Kexin XieFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Yue CuiFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Deming JiangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Zhongyun ChenFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Haitian NanFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Pedro Rosa-NetoFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu).
Jie LuFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu) wmywly@hotmail.com imaginglu@hotmail.com.
Liyong WuFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (Liu, Chu, Xie, Cui, Jiang, Chen, Nan, Wu); the Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (Yan, Lu); the Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China (Nie); the School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China (Nie); the McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, Montreal, Que. (Rosa-Neto); the Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China (Lu) wmywly@hotmail.com imaginglu@hotmail.com.
Capital Medical University · CNChinese Academy of Sciences · CNMcGill University Health Centre · CAUniversity of Chinese Academy of Sciences · CNInstitute of High Energy Physics · CN

Funding

CIHR FRN 152985CIHR MOP-11-51-31CIHR PI:PR-N
6 · The paper itself

Abstract

backgroundThere is growing evidence that the striatum plays a central role in cognitive dysfunction. However, it remains unclear whether and how the striatum contributes specifically to executive deficits in Alzheimer disease (AD). We sought to elucidate aberrations in the striatal subregion associated with executive function and its metabolic connectivity with the cortical regions to investigate its role in the pathogenesis of executive deficits in patients with AD.

methodsPatients with AD and healthy controls underwent a neuropsychological assessment battery, including assessment of executive function, and a hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) scan. We performed voxel-wise analyses of cerebral metabolism between patients and controls, focusing on the executive subregion of the striatum according to the Oxford-GSK-Imanova Striatal Connectivity Atlas. We assessed the correlation between the [

resultsWe included 50 patients with AD and 33 controls in our analyses. The patterns of striatal hypometabolism in patients with AD were specific to executive and caudal motor subregions. Metabolic activity in the executive subregion of the striatum correlated negatively with the severity of executive dysfunction, as measured with the Trial-Making Test (TMT) part B and the difference score TMT B-A, and correlated positively with Digit Span (backward) and Verbal Fluency Test scales, particularly on the left side. Compared with controls, patients with AD showed reduced metabolic connectivity between striatal executive subregions and the dorsolateral prefrontal cortex (DLPFC). LIMITATIONS: Our study was limited by small sample sizes and cross-sectional findings.

conclusionOur findings show that patients with AD have impairments in the executive subregion of the striatum, and these deficits may be associated with a disconnection between the executive striatum and DLPFC, providing valuable insight into the pathogenesis of this disease.

Indexed as

Alzheimer DiseaseCase-Control StudiesCorpus StriatumCross-Sectional StudiesExecutive FunctionHumansMagnetic Resonance ImagingNeostriatum

Identifiers

PMID37045477
PMCPMC10095253
OpenAlexW4365144124

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.