Evidence map›Paper›PMID 37045473›Full record

ArticleJournal for immunotherapy of cancer2023

Specific recognition of an

Bradley Sinclair White, Sivasish Sindiri, Victoria Hill, Billel Gasmi, Shirley Nah, Jared J Gartner, Todd D Prickett, Yong Li, Devikala Gurusamy, Paul Robbins and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Facts and Hopes for Neoantigen-Enriched TIL.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Bradley Sinclair WhiteSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Sivasish SindiriSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0003-2516-969X
Victoria HillSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Billel GasmiSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Shirley NahSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Jared J GartnerSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Todd D PrickettSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Yong LiSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Devikala GurusamySurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Paul RobbinsSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-1260-8123
Steven A RosenbergSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA.
Vid LekoSurgery Branch, National Cancer Institute, Bethesda, Maryland, USA vid.leko@nih.gov.ORCID 0000-0001-7883-5030
National Cancer Institute · US

Funding

Adoptive Cell Transfer Immunotherapy of CancerZIABC010984 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2025
$56.8M
DNA Sequencing and FACS Core FacilitiesZICBC010948 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROBBINS, PAUL · 2009 to 2025
$35.6M
Targeting cancer neoantigens in patients with myeloid malignanciesZIABC012116 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LEKO, VID · 2022 to 2025
$2.2M
6 · The paper itself

Abstract

backgroundMetastatic cholangiocarcinoma (CC), a form of gastrointestinal cancer that originates from the bile ducts, cannot be cured by currently available therapies, and is associated with dismal prognosis. In a previous case report, adoptive transfer of autologous tumor infiltrating lymphocytes (TILs), the majority of which recognized a tumor-specific point mutation, led to a profound and durable cancer regression in a patient with metastatic CC. Thus, more effective treatment for patients with this disease may be developed by using TILs that target cancer-specific mutations, but also other genetic aberrations such as gene fusions. In this context, fusions that involve

methodTo address whether

resultsWe found that CD4

conclusionsThis finding suggests that

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaBile Ducts, IntrahepaticHumansLymphocytes, Tumor-InfiltratingReceptor, Fibroblast Growth Factor, Type 2FGFR2 protein, humanReceptor, Fibroblast Growth Factor, Type 2AntigensGastrointestinal NeoplasmsImmunotherapy, AdoptiveLymphocytes, Tumor-InfiltratingTranslational Medical Research

Identifiers

PMID37045473
PMCPMC10106037
OpenAlexW4365143458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.