Evidence map›Paper›PMID 37045472›Full record

ArticleLife science alliance2023

Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.

Shogo Tsuji, Cynthia S Brace, Ruiqing Yao, Yoshitaka Tanie, Hirobumi Tada, Nicholas Rensing, Seiya Mizuno, Julio Almunia, Yingyi Kong, Kazuhiro Nakamura and 7 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. [Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  4. Sleep advances : a journal of the Sleep Research Society · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Shogo TsujiDepartment of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.
Cynthia S BraceDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Ruiqing YaoDepartment of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.
Yoshitaka TanieDepartment of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.
Hirobumi TadaDepartment of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.ORCID https://orcid.org/0000-0002-6098-7826
Nicholas RensingDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Seiya MizunoLaboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan.ORCID https://orcid.org/0000-0002-6740-5817
Julio AlmuniaLaboratory of Experimental Animals, NCGG, Obu, Japan.
Yingyi KongDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuhiro NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-6095-8996
Takahisa FurukawaLaboratories for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka, Japan.
Noboru OgisoLaboratory of Experimental Animals, NCGG, Obu, Japan.ORCID https://orcid.org/0000-0003-3839-786X
Shinya ToyokuniDepartment of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-5757-1109
Satoru TakahashiLaboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan.ORCID https://orcid.org/0000-0002-8540-7760
Michael WongDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0002-3796-743X
Shin-Ichiro ImaiDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID https://orcid.org/0000-0003-3742-5777
Akiko SatohDepartment of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan asatoh@ncgg.go.jp.ORCID https://orcid.org/0000-0002-6139-2808
Washington University in St. Louis · USNagoya University · JPNational Center for Geriatrics and Gerontology · JPUniversity of Tsukuba · JPProtein Research Foundation · JPShigakkan University · JPTohoku University · JP

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
ENAMPT-MEDIATED ADIPO-HYPOTHALAMIC COMMUNICATION FOR NAD+ PRODUCTION AND AGINGR01AG047902 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2014 to 2023
$3.2M
THE ROLE OF DORSOMEDIAL HYPOTHALAMIC NEURONS IN MAMMALIAN AGING AND LONGEVITYR01AG037457 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2011 to 2020
$3.1M
NIA NIH HHS R01 AG037457NIA NIH HHS R01 AG047902NICHD NIH HHS P50 HD103525NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Old animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus (DMH) are activated during sleep deprivation (SD) in young mice but not in old mice. Chemogenetic inhibition of Prdm13+ neurons in the DMH in young mice promotes increase in sleep attempts during SD, suggesting its involvement in sleep control. Furthermore, DMH-specific

Indexed as

HypothalamusSleep DeprivationAnimalsDietHistone-Lysine N-MethyltransferaseMiceObesitySleepTranscription FactorsHistone-Lysine N-MethyltransferasePrdm13 protein, mouseTranscription Factors

Identifiers

PMID37045472
PMCPMC10105329
OpenAlexW4365142880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.