ArticleNeurosciences (Riyadh, Saudi Arabia)2023
Changes in routine blood parameters of patients with generalized tonic clonic seizure: a retrospective study.
Article in Neurosciences (Riyadh, Saudi Arabia), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Platelet-to-lymphocyte ratio as an indicator of idiopathic epilepsy in dogs.Journal of veterinary internal medicine · 2026Article
- Standard complete blood count to predict long-term outcomes in febrile infection-related epilepsy syndrome (FIRES): A multicenter study.Epilepsia · 2025Article
- From Immersion to Seizure: A Novel Case of Water Intoxication Complicating a Water Birth.Cureus · 2025Article
- Risk factors for secondary epilepsy in children with viral encephalitis.American journal of translational research · 2025Article
- Neutrophil-to-Lymphocyte Ratio as a Potential Predictive Marker for Epileptic Seizures: Unveiling the "V"-Shaped Link.Mediators of inflammation · 2025Article
- Evaluation of Blood C Reactive Protein (CRP) and Neutrophil-to-Lymphocyte Ratio (NLR) Utility in Canine Epilepsy.Veterinary sciences · 2024Article
- Association between platelet to white blood cell ratio and post-stroke epilepsy in patients with acute ischemic stroke: a multicenter retrospective cohort study.Frontiers in neurologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo analyze the alterations in routine blood parameters in these patients. Generalized tonic clonic seizure (GTCS) is one main type of generalized epilepsy. Clinicians have recently found changes in routine blood parameters in GTCS patients.
methodsA retrospective study of 45 GTCS patients and 200 healthy controls was conducted. Blood routine tests in emergency ward and on the second day of admission were retrieved. Changes in routine blood parameters, including red blood cell (RBC) count, white blood cell (WBC) count, platelet count, lymphocyte count, neutrophil count, and neutrophil-to-lymphocyte ratio (NLR) on the seizure episode day and the second day after seizure were analyzed.
resultsThe GTCS patients had increased platelet count, RBC count, WBC count, neutrophil count, lymphocyte count, and NLR, especially at onset of GTCS episode, compared to the controls. These parameters had decreased on the second day after seizure onset. The neutrophil count and WBC count in GTCS cases with seizure duration <5 min were significantly lower than those with seizure duration >5 min. However, this phenomenon was not observed in other indices.
conclusionThe GTCS may induce a transient increase in RBC count, WBC count, and platelet count, and obvious elevation in neutrophil count. There is a certain correlation between WBC count and the duration of seizures. Changes in routine blood parameters observed in GTCS patients may provide useful information clinically.
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