Evidence map›Paper›PMID 37045461›Full record

ReviewNeurosciences (Riyadh, Saudi Arabia)2023

The future of alzheimer disease immunotherapies in Saudi Arabia: Consensus statement of the Saudi Chapter of Cognitive and Behavioral Neurology.

Haythum O Tayeb, Roaa A Khallaf, Taim A Muayqil, Walid A Alkeridy, Fawwaz S Alibrahim, Omar A Alfaify, Najeeb Qadi, Frank I Tarazi

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosciences (Riyadh, Saudi Arabia), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haythum O TayebFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Roaa A KhallafFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Taim A MuayqilFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Walid A AlkeridyFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Fawwaz S AlibrahimFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Omar A AlfaifyFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Najeeb QadiFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.
Frank I TaraziFrom The Neuroscience Research Unit and the Mind and Brain Studies Initiative (Tayeb), Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, from the Department of neurology (Khallaf), Neuroscience Center, King Fahad Specialist Hospital Dammam, from Neurology Unit (Muayqil), from the the Department of Medicine (Alkeridy), College of Medicine, King Saud University, Riyadh, from the Neurology Division (Alibrahim), Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from the Department of Neurology (Alfaify), Prince Sultan Military Medical City, from the Neuroscience Centre (Qadi), King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, and from the Department of Psychiatry and Neuroscience (Tarazi), Harvard Medical School and McLean Hospital, Belmont, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer Disease (AD) constitutes a major global healthcare problem. Standard AD pharmacotherapies offer only modest transient cognitive and behavioral benefits. Aducanumab, an amyloid monoclonal antibody, was the first disease modifying agent to be approved for AD treatment. However, concerns about its efficacy and side effects led regulatory institutions around the world to restrict its use. Lecanemab was the second amyloid antibody to receive accelerated approval for use in early AD. This review and consensus statement was prepared by the Saudi Chapter of Cognitive and Behavioral Neurology to review the current developments in AD immunotherapies from a Saudi perspective. We outline recommendations with regards to offering aducanumab and other future immunotherapies to Saudi AD patients. We describe resources, infrastructure, research, and clinical practice changes that must be attained to transform the patient journey and clinical pathways of AD in Saudi Arabia to enable offering AD immunotherapies in Saudi Arabia.

Indexed as

Alzheimer DiseaseNeurologyCognitionHumansImmunotherapySaudi Arabia

Identifiers

PMID37045461
PMCPMC10155484

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