ArticleChemosphere2023
Algal ciguatoxin identified as source of ciguatera poisoning in the Caribbean.
Article in Chemosphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Convergent Total Synthesis of Caribbean Ciguatoxin C-CTX1 and Its C3-Epimer.Journal of the American Chemical Society · 2026Article
- Article
- Comparison of LC-MS methods for the quantitation of ciguatoxins in fish - A collaborative study.Food chemistry: X · 2025Article
- A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests FewToxins · 2025Article
- Article
- Comparison of Different Solid-Phase Cleanup Methods Prior to the Detection of Ciguatoxins in Fish by Cell-Based Assay and LC-MS/MS.Journal of agricultural and food chemistry · 2025Article
- Review
- Recent progress in the application of chromatography-coupled mass-spectrometry in the analysis of contaminants in food products.Food chemistry: X · 2025Article
- Automatic MS/MS Data Mining Strategy for Rapid Screening of Polyether Toxins Derived fromAnalytical chemistry · 2025Article
- Application of High-Resolution Mass Spectrometry for Ciguatoxin Detection in Fish from the Asia-Pacific Region.Toxins · 2025Article
- First Confirmed Occurrence of Ciguatera Poisoning in the UK from Imported Pinjalo Snapper (Marine drugs · 2025Article
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Article
- Isolation of Caribbean Ciguatoxin-5 (C-CTX5) and confirmation of its structure by NMR spectroscopy.Tetrahedron · 2024Article
- First Detection of Algal Caribbean Ciguatoxin in Amberjack Causing Ciguatera Poisoning in the Canary Islands (Spain).Toxins · 2024Article
- Targeted Metabolite Fingerprints of ThirteenMarine drugs · 2024Article
- Article
- Article
- 3-Epimers of Caribbean ciguatoxins in fish and algae.Toxicon : official journal of the International Society on Toxinology · 2024Article
- Gambierdiscus species diversity and community structure in St. Thomas, USVI and the Florida Keys, USA.Harmful algae · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Ciguatera poisoning (CP) is a severe seafood-borne disease, caused by the consumption of reef fish contaminated with Caribbean ciguatoxins (C-CTXs) in the Caribbean and tropical Atlantic. However, C-CTXs have not been identified from their presumed algal source, so the relationship to the CTXs in fish causing illness remains unknown. This has hindered the development of detection methods, diagnostics, monitoring programs, and limited fundamental knowledge on the environmental factors that regulate C-CTX production. In this study, in vitro and chemical techniques were applied to unambiguously identify a novel C-CTX analogue, C-CTX5, from Gambierdiscus silvae and Gambierdiscus caribaeus strains from the Caribbean. Metabolism in vitro by fish liver microsomes converted algal C-CTX5 into C-CTX1/2, the dominant CTX in ciguatoxic fish from the Caribbean. Furthermore, C-CTX5 from G. silvae was confirmed to have voltage-gated sodium-channel-specific activity. This finding is crucial for risk assessment, understanding the fate of C-CTXs in food webs, and is a prerequisite for development of effective analytical methods and monitoring programs. The identification of an algal precursor produced by two Gambierdiscus species is a major breakthrough for ciguatera research that will foster major advances in this important seafood safety issue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.