Evidence map›Paper›PMID 37044091›Full record

ArticleCell reports. Medicine2023

Using less annotation workload to establish a pathological auxiliary diagnosis system for gastric cancer.

Junlin Lan, Musheng Chen, Jianchao Wang, Min Du, Zhida Wu, Hejun Zhang, Yuyang Xue, Tao Wang, Lifan Chen, Chaohui Xu and 6 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Junlin LanCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Musheng ChenDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China.
Jianchao WangDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China.
Min DuCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Zhida WuDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China.
Hejun ZhangDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China.
Yuyang XueSchool of Engineering, University of Edinburgh, Edinburgh EH8 9JU, UK.
Tao WangCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Lifan ChenDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China.
Chaohui XuCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Zixin HanCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Ziwei HuCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Yuanbo ZhouCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Xiaogen ZhouCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China.
Tong TongCollege of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350108, China; Key Lab of Medical Instrumentation & Pharmaceutical Technology of Fujian Province, Fuzhou University, Fuzhou, Fujian 350108, China; Imperial Vision Technology, Fuzhou, Fujian 350100, China. Electronic address: ttraveltong@gmail.com.
Gang ChenDepartment of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350014, China. Electronic address: naichengang@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological diagnosis of gastric cancer requires pathologists to have extensive clinical experience. To help pathologists improve diagnostic accuracy and efficiency, we collected 1,514 cases of stomach H&E-stained specimens with complete diagnostic information to establish a pathological auxiliary diagnosis system based on deep learning. At the slide level, our system achieves a specificity of 0.8878 while maintaining a high sensitivity close to 1.0 on 269 biopsy specimens (147 malignancies) and 163 surgical specimens (80 malignancies). The classified accuracy of our system is 0.9034 at the slide level for 352 biopsy specimens (201 malignancies) from 50 medical centers. With the help of our system, the pathologists' average false-negative rate and average false-positive rate on 100 biopsy specimens (50 malignancies) are reduced to 1/5 and 1/2 of the original rates, respectively. At the same time, the average uncertainty rate and the average diagnosis time are reduced by approximately 22% and 20%, respectively.

Indexed as

Stomach NeoplasmsBiopsyHumansWorkloadauxiliary diagnosisdeep learninggastric cancerpathological

Identifiers

PMID37044091
PMCPMC10140598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.