Evidence map›Paper›PMID 37044088›Full record

ArticleNeuron2023

Putative cell-type-specific multiregional mode in posterior parietal cortex during coordinated visual behavior.

Mohammad Farhan Khazali, Yan T Wong, Heather L Dean, Maureen A Hagan, Margaret M Fabiszak, Bijan Pesaran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. A causal role for the posterior corpus callosum in bimanual coordination.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Mohammad Farhan KhazaliCenter for Neural Science, New York University, New York, NY 10003, USA; Freiburg Epilepsy Center, Medical Center - University of Freiburg, 79106 Freiburg, Germany.
Yan T WongDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Electrical and Computer Systems Engineering, Monash University, Clayton, VIC 3800, Australia.
Heather L DeanCenter for Neural Science, New York University, New York, NY 10003, USA.
Maureen A HaganDepartment of Physiology and Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Margaret M FabiszakCenter for Neural Science, New York University, New York, NY 10003, USA.
Bijan PesaranCenter for Neural Science, New York University, New York, NY 10003, USA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 190104, USA; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 190104, USA; Department of Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 190104, USA. Electronic address: pesaran@upenn.edu.
New York University · USAustralian Regenerative Medicine Institute · AUUniversity of Freiburg · DE

Funding

Vision Core Grant- Design and Fabrication ModuleP30EY013079 · NEI · NEW YORK UNIVERSITY · PI ANGELAKI, DORA · 2000 to 2025
$14.2M
TRAINING IN VISUAL NEUROSCIENCET32EY007136 · NEI · NEW YORK UNIVERSITY · PI J ANTHONY MOVSHON · 1993 to 2026
$5.3M
Multiple spatial representations during visually-guided behaviorR01EY024067 · NEI · NEW YORK UNIVERSITY · PI PESARAN, BIJAN · 2014 to 2018
$1.9M
CRCNS: Reinforcement learning in multi-dimensional action spacesR01MH087882 · NIMH · NEW YORK UNIVERSITY · PI DAW, NATHANIEL DOUGLASS · 2009 to 2013
$1.8M
Neural mechanisms of multiregional communication during coordinated visual behaviorR01EY035826 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Bijan Pesaran · 2024 to 2026
$1.8M
NEI NIH HHS P30 EY013079NEI NIH HHS R01 EY024067NEI NIH HHS R01 EY035826NEI NIH HHS T32 EY007136NIMH NIH HHS R01 MH087882
6 · The paper itself

Abstract

In the reach and saccade regions of the posterior parietal cortex (PPC), multiregional communication depends on the timing of neuronal activity with respect to beta-frequency (10-30 Hz) local field potential (LFP) activity, termed dual coherence. Neural coherence is believed to reflect neural excitability, whereby spiking tends to occur at a particular phase of LFP activity, but the mechanisms of multiregional dual coherence remain unknown. Here, we investigate dual coherence in the PPC of non-human primates performing eye-hand movements. We computationally model dual coherence in terms of multiregional neural excitability and show that one latent component, a multiregional mode, reflects shared excitability across distributed PPC populations. Analyzing the power in the multiregional mode with respect to different putative cell types reveals significant modulations with the spiking of putative pyramidal neurons and not inhibitory interneurons. These results suggest a specific role for pyramidal neurons in dual coherence supporting multiregional communication in PPC.

Indexed as

NeuronsParietal LobeAction PotentialsAnimalsPyramidal Cellsarm movementscoordinated behavioreye movementsmultiregional communicationposterior parietalputative cell typespike waveform

Identifiers

PMID37044088
PMCPMC10935574
OpenAlexW4364381758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.