Evidence map›Paper›PMID 37043739›Full record

ArticleJournal of natural products2023

Modulation of

Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Aswad KhadilkarDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, California 95964, United States.
Zoie L BunchDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27412, United States.
Jessica WagonerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195,United States.
Vandana RavindranOslo Centre for Biostatistics and Epidemiology (OCBE), Faculty of Medicine, University of Oslo, Oslo 0313, Norway.
Jessica M OdaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195,United States.
Warren S VidarDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27412, United States.
Trevor N ClarkDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Preston K ManwillDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27412, United States.ORCID 0000-0002-6072-1067
Daniel A ToddDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27412, United States.
Sarah A BarrDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.
Lauren K OlingerDepartment of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.
Susan L FinkDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195,United States.ORCID 0000-0003-1705-0103
Wendy K StrangmanDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28403, United States.ORCID 0000-0002-6911-4909
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0003-1818-4971
John B MacMillanDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, California 95964, United States.ORCID 0000-0003-1430-1077
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27412, United States.ORCID 0000-0001-6773-746X
Stephen J PolyakDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington 98195,United States.ORCID 0000-0001-7475-9827
University of North Carolina at Greensboro · USUniversity of Washington · USUniversity of North Carolina Wilmington · USSimon Fraser University · CAUniversity of California, Santa Cruz · USUniversity of Oslo · NO

Funding

Urgent Covid-19 Revision to the Center for High-Throughput Functional Annotation of Natural ProductsU41AT008718 · NCCIH · UT SOUTHWESTERN MEDICAL CENTER · PI CECH, NADJA B, LININGTON, ROGER G · 2015 to 2024
$10.1M
Role of IRE1 Alpha in Coronavirus InfectionsR01AI162684 · NIAID · UNIVERSITY OF WASHINGTON · PI Susan Leilani Fink · 2022 to 2026
$2.8M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
NCCIH NIH HHS T32 AT008938NCCIH NIH HHS U41 AT008718NIAID NIH HHS R01 AI162684
6 · The paper itself

Abstract

Botanical natural products have been widely consumed for their purported usefulness against COVID-19. Here, six botanical species from multiple sources and 173 isolated natural product compounds were screened for blockade of wild-type (WT) SARS-CoV-2 infection in human 293T epithelial cells overexpressing ACE-2 and TMPRSS2 protease (293TAT). Antiviral activity was demonstrated by an extract from

Indexed as

AlkaloidsAntineoplastic AgentsBenzylisoquinolinesCOVID-19StephaniaStephania tetrandraAntiviral AgentsHumansPlant ExtractsSARS-CoV-2AlkaloidsAntineoplastic AgentsAntiviral AgentsBenzylisoquinolinesPlant Extracts

Identifiers

PMID37043739
PMCPMC10108733
OpenAlexW4365138327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.