ArticleScience advances2023
Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Thermosensitive citrate-based mussel-inspired attack-defense integrated bioadhesives facilitate complicated wound healing.Bioactive materials · 2026Article
- Harnessing Surface Instabilities for Functional Materials: Mechanics, Morphology, and Emerging Applications.Nano-micro letters · 2026Review
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cocrystal effect-driven ultrafast phase-transition ionogel for dynamically switchable adhesion interfaces.Nature communications · 2025Article
- Reversible biobased adhesives enable closed-loop engineered composites.Nature communications · 2025Article
- Bio-Inspired Interlocking Micro-Patterning for Tunable, Switchable and Selective Adhesion in Wet and Dusty Environments.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Mucus-Inspired Supramolecular Adhesives: Exploring the Synergy between Dynamic Networks and Functional Liquids.ACS nano · 2025Review
- Recent advancements in smart responsive tissue adhesives for medical applications.Frontiers in medicine · 2025Review
- An Environmentally Stable, Biocompatible, and Multilayered Wound Dressing Film with Reversible and Strong Adhesion.Advanced healthcare materials · 2024Article
- Strong and Thermo-Switchable Gel Adhesion Based on UCST-Type Phase Transition in Deep Eutectic Solvent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival.Biomaterials research · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Switchable and minimally invasive tissue adhesives have great potential for medical applications. However, on-demand adherence to and detachment from tissue surfaces remain difficult. We fabricated a switchable hydrogel film adhesive by designing pattern-tunable wrinkles to control adhesion. When adhered to a substrate, the compressive stress generated from the bilayer system leads to self-similar wrinkling patterns at short and long wavelengths, regulating the interfacial adhesion. To verify the concept and explore its application, we established a random skin flap model, which is a crucial strategy for repairing severe or large-scale wounds. Our hydrogel adhesive provides sufficient adhesion for tissue sealing and promotes neovascularization at the first stage, and then gradually detaches from the tissue while a dynamic wrinkling pattern transition happens. The gel film can be progressively ejected out from the side margins after host-guest integration. Our findings provide insights into tunable bioadhesion by manipulating the wrinkling pattern transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.