ArticleScience advances2023
A conserved hymenopteran-specific family of cytochrome P450s protects bee pollinators from toxic nectar alkaloids.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Coordinated P450-UGT detoxification contributes to furanocoumarin tolerance associated with host plant range divergence in Helicoverpa.PLoS biology · 2026Article
- Species-specific brain transcriptomic responses to clothianidin and sulfoxaflor in pollinators.iScience · 2026Article
- Review
- The evolving landscape of pharmacogenomics: Current achievements and future directions.Pharmacological reviews · 2026Review
- Comparative lipidomic and proteomic analysis reveals species-specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris.Pest management science · 2026Article
- Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026Review
- Physiological Response ofInsects · 2025Article
- Caver Web 2.0: analysis of tunnels and ligand transport in dynamic ensembles of proteins.Nucleic acids research · 2025Article
- Identification and expression of detoxification genes provide insights into host adaptation of the walnut pest Atrijuglans aristata.BMC genomics · 2025Article
- Leveraging Transcriptional Signatures of Diverse Stressors for Bumble Bee Conservation.Molecular ecology · 2025Article
- Pollen products collected from honey bee hives experiencing minor stress have altered fungal communities and reduced antimicrobial properties.FEMS microbiology ecology · 2024Article
- UDP-glycosyltransferases act as key determinants of host plant range in generalist and specialistProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees.Evolutionary applications · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many plants produce chemical defense compounds as protection against antagonistic herbivores. However, how beneficial insects such as pollinators deal with the presence of these potentially toxic chemicals in nectar and pollen is poorly understood. Here, we characterize a conserved mechanism of plant secondary metabolite detoxification in the Hymenoptera, an order that contains numerous highly beneficial insects. Using phylogenetic and functional approaches, we show that the CYP336 family of cytochrome P450 enzymes detoxifies alkaloids, a group of potent natural insecticides, in honeybees and other hymenopteran species that diverged over 281 million years. We linked this function to an aspartic acid residue within the main access channel of CYP336 enzymes that is highly conserved within this P450 family. Together, these results provide detailed insights into the evolution of P450s as a key component of detoxification systems in hymenopteran species and reveal the molecular basis of adaptations arising from interactions between plants and beneficial insects.
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